Pain disorders are associated with aberrant oscillations in the pain-related cortical regions; however, few studies have investigated the relationship between the functional cortical network and migraine chronification through direct neural signals. Magnetoencephalography was used to record the resting-state brain activity of healthy controls as well as patients with episodic migraine (EM) and chronic migraine (CM). The source-based oscillatory dynamics of the pain-related cortical regions, which comprises 10 node regions (the bilateral primary [SI] and secondary somatosensory cortices, insula, medial frontal cortex, and anterior cingulate cortex [ACC]), were calculated to determine the intrinsic connectivity and node strength at 1 to 40 Hz. The total node strength within the pain-related cortical regions was smaller in the beta band in patients with migraine (70 EM and 80 CM) than in controls (n = 65). In the beta band, the node strength and functional connectivity values of patients with CM and patients with EM differed from those of controls in specific cortical areas, notably the left SI (EM < control) and bilateral ACC (CM < control); moreover, the node strength was lower in patients with CM than in those with EM. In all patients with migraine, negative correlations were observed between headache frequency and node strength in the bilateral ACC. In conclusion, migraine is characterized by reduced beta oscillatory connectivity within the pain-related cortical regions. Reduced beta connectivity in the ACC is linked to migraine chronification. Longitudinal studies should verify whether this oscillation change is a brain signature and a potential neuromodulation target for migraine.

中文翻译：

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偏头痛慢性化与疼痛相关皮层区域内的 β 波段连通性有关：脑磁图研究。

疼痛障碍与疼痛相关皮质区域的异常振荡有关；然而，很少有研究通过直接神经信号研究功能性皮层网络与偏头痛慢性化之间的关系。脑磁图用于记录健康对照以及发作性偏头痛 (EM) 和慢性偏头痛 (CM) 患者的静息状态大脑活动。计算由 10 个节点区域（双侧初级 [SI] 和次级躯体感觉皮层、岛叶、内侧额叶皮层和前扣带回皮层 [ACC]）组成的疼痛相关皮层区域的基于源的振荡动力学，以确定1 到 40 Hz 的内在连接和节点强度。与对照组（n = 65）相比，偏头痛患者（70 EM 和 80 CM）的 β 波段疼痛相关皮质区域内的总淋巴结强度更小。在β波段，CM患者和EM患者的节点强度和功能连接值在特定皮质区域与对照组不同，尤其是左侧SI（EM<对照）和双侧ACC（CM<对照）；此外，CM 患者的淋巴结强度低于 EM 患者。在所有偏头痛患者中，头痛频率与双侧 ACC 淋巴结强度呈负相关。总之，偏头痛的特征是疼痛相关皮层区域内的β振荡连接减少。ACC 中减少的 Beta 连通性与偏头痛慢性化有关。