PURPOSE This study aims to evaluate the effects of a VLCKD combined with omega-3 supplementation (VLCKD diet only lasted for some weeks, and it was followed by a non-ketogenic LCD for the rest of the study period) on body composition, visceral fat, satiety hormones, inflammatory and metabolic markers. METHODS It has been performed a pilot open label study lasted 90 days, in a cohort of 12 women with class I obesity aged 18 to 65 years. Data on body composition (evaluated by Dual X-Ray Absorptiometry-DXA), visceral fat, satiety hormones, inflammatory and metabolic markers were recorded. RESULTS This study showed a body weight reduction mean difference over time of -13.7 kg and the waist circumference mean difference decrease of -13.3 cm. Also, the fat mass (FM) decreased-9.1 kg and visceral adipose tissue (VAT)-0.41 kg. No effects on fat-free mass (FFM) have been reported. Improvements were observed in the satiety hormones, with increased ghrelin and decreased leptin, and also in the metabolic profiles. CONCLUSIONS A VLCKD combined with omega-3 supplementation appears to be an effective strategy for promoting an high loss of FM with preservation of FFM in patients with class I obesity.

中文翻译：

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极低热量生酮饮食与 omega-3 结合对炎症、饱腹感激素、身体成分和代谢标志物的影响。对 I 级肥胖受试者的试点研究。


目的本研究旨在评估 VLCKD 结合 omega-3 补充剂（VLCKD 饮食仅持续几周，随后在研究期间的剩余时间内采用非生酮 LCD）对身体成分、内脏脂肪的影响、饱腹感激素、炎症和代谢标志物。方法 我们对 12 名年龄在 18 至 65 岁之间的 I 级肥胖女性进行了一项为期 90 天的试点开放标签研究。记录身体成分（通过双 X 射线吸收测定法-DXA 评估）、内脏脂肪、饱腹感激素、炎症和代谢标记物的数据。结果 这项研究显示，随着时间的推移，体重平均差异减少了 -13.7 公斤，腰围平均差异减少了 -13.3 厘米。此外，脂肪量（FM）减少了 9.1 公斤，内脏脂肪组织（VAT）减少了 0.41 公斤。尚未报告对去脂体重 (FFM) 产生影响。我们观察到饱腹感激素有所改善，胃饥饿素增加，瘦素减少，代谢状况也有所改善。结论 VLCKD 联合 omega-3 补充剂似乎是促进 I 级肥胖患者 FM 大量丧失并保留 FFM 的有效策略。