PURPOSE The impact of exercise on health-related quality of life (HRQOL) in patients with glioma remains unknown. We hypothesized that glioma patients with low exercise tolerance experience more distress in HRQOL sleep and fatigue domains than patients with high tolerance to exercise. METHODS Thirty-eight male and female patients with low- or high-grade glioma treated at a single tertiary care institution participated. Patients completed a validated telephone survey to determine their exercise habits before and following diagnosis. An unpaired t-test was run to measure the interaction between exercise tolerances on HRQOL functional and impairment domains. RESULTS Those with low pre-morbid physical activity levels had more distress in HRQOL sleep and fatigue domains. The effects were independent of plasma brain-derived neurotrophic factor (BDNF) levels and the degree of exercise did not appear to impact plasma BDNF in adult glioma patients. CONCLUSIONS The aim of this study was to examine the significance of exercise habits on perioperative functional outcomes in patients with low-grade or high-grade glioma. We found that glioma patients with low tolerance to exercise had more sleep disturbances and greater fatigue than glioma patients with high tolerance to exercise. Furthermore, exercise tolerance in the adult glioma population does not appear to impact plasma BDNF secretion.

中文翻译：

---

运动可改善成人高级别和低级别神经胶质瘤患者的健康相关生活质量睡眠和疲劳领域。

目的 运动对神经胶质瘤患者健康相关生活质量 (HRQOL) 的影响仍然未知。我们假设，与运动耐受性高的患者相比，运动耐受性低的神经胶质瘤患者在 HRQOL 睡眠和疲劳领域经历更多的痛苦。方法 38 名在一家三级医疗机构接受治疗的低级别或高级神经胶质瘤男性和女性患者参与。患者完成了一项经过验证的电话调查，以确定他们在诊断前后的锻炼习惯。运行未配对 t 检验以测量 HRQOL 功能域和损伤域的运动耐量之间的相互作用。结果 那些病前体力活动水平低的人在 HRQOL 睡眠和疲劳领域有更多的痛苦。这些影响与血浆脑源性神经营养因子 (BDNF) 水平无关，运动程度似乎不会影响成年神经胶质瘤患者的血浆 BDNF。结论 本研究的目的是检查运动习惯对低级别或高级神经胶质瘤患者围手术期功能结果的意义。我们发现，与运动耐受性高的神经胶质瘤患者相比，运动耐受性低的神经胶质瘤患者睡眠障碍和疲劳程度更高。此外，成人神经胶质瘤人群的运动耐量似乎不会影响血浆 BDNF 分泌。结论 本研究的目的是检查运动习惯对低级别或高级神经胶质瘤患者围手术期功能结果的意义。我们发现，与运动耐受性高的神经胶质瘤患者相比，运动耐受性低的神经胶质瘤患者睡眠障碍和疲劳程度更高。此外，成人神经胶质瘤人群的运动耐量似乎不会影响血浆 BDNF 分泌。结论 本研究的目的是检查运动习惯对低级别或高级神经胶质瘤患者围手术期功能结果的意义。我们发现，与运动耐受性高的神经胶质瘤患者相比，运动耐受性低的神经胶质瘤患者睡眠障碍和疲劳程度更高。此外，成人神经胶质瘤人群的运动耐量似乎不会影响血浆 BDNF 分泌。