Abstract

Two new transition metal coordination polymers (CPs), namely, [Co₂(OH)(TZI)(DMA)] (1) and [Mn₂(OH)(TZI)(H₂O)₂] (2) have been synthesized under solvo-/hydrothermal conditions via using a bifunctional organic ligand 5-(1H-tetrazol-5-yl)isophthalic acid (H₃TZI). Their treatment activity on the renal ischemia-reperfusion injury was evaluated and the related mechanism was explored at the same time. The ELISA detection kit was conducted to measure the levels of the inflammatory cytokines IL-1β and TNF-α released by the epithelial cells in distal tubules. In addition to this, the HE staining was further conducted to confirm the pathological damage levels in the kidney tissue.

摘要

两种新的过渡金属配位聚合物（CP），即[Co ₂ (OH)(TZI)(DMA)] ( 1 ) 和[Mn ₂ (OH)(TZI)(H ₂ O) ₂ ] ( 2 )在溶剂-/水热条件下通过使用双功能有机配体 5-(1 H-四唑-5-基) 间苯二甲酸 (H ₃TZI）。评价了它们对肾缺血再灌注损伤的治疗作用，同时探讨了相关机制。ELISA检测试剂盒检测远端小管上皮细胞释放的炎性细胞因子IL-1β和TNF-α水平。除此之外，进一步进行HE染色以确认肾组织中的病理损伤水平。