The emerging therapeutic potential of extracellular vesicles in trauma,Journal of Leukocyte Biology

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The emerging therapeutic potential of extracellular vesicles in trauma
Journal of Leukocyte Biology ( IF 3.6 ) Pub Date : 2021-09-17 , DOI: 10.1002/jlb.3mir0621-298r
Nijmeh Alsaadi ₁ , Amudan J Srinivasan ₁ , Anupamaa Seshadri ₁ , Matthew Shiel ₂ , Matthew D Neal _{1,

3} , Melanie J Scott _{1,

3}

Affiliation

Traumatic injury is a major cause of morbidity and mortality worldwide, despite significant advances in treatments. Most deaths occur either very early, through massive head trauma/CNS injury or exsanguination (despite advances in transfusion medicine), or later after injury often through multiple organ failure and secondary infection. Extracellular vesicles (EVs) are known to increase in the circulation after trauma and have been used to limited extent as diagnostic and prognostic markers. More intriguingly, EVs are now being investigated as both causes of pathologies post trauma, such as trauma-induced coagulopathy, and as potential treatments. In this review, we highlight what is currently known about the role and effects of EVs in various aspects of trauma, as well as exploring current literature from investigators who have begun to use EVs therapeutically to alter the physiology and pathology of traumatic insults. The potential effectiveness of using EVs therapeutically in trauma is supported by a large number of experimental studies, but there is still some way to go before we understand the complex effects of EVs in what is already a complex disease process.

中文翻译：

细胞外囊泡在创伤中的新兴治疗潜力

尽管治疗方法取得了重大进展，但创伤性损伤仍然是全世界发病和死亡的主要原因。大多数死亡要么发生在很早的时候，通过严重的头部创伤/中枢神经系统损伤或失血（尽管输血医学取得了进步），要么发生在受伤后，通常通过多器官衰竭和继发感染。众所周知，细胞外囊泡（EV）在创伤后循环中会增加，并且已在有限程度上用作诊断和预后标志物。更有趣的是，目前正在研究 EV 作为创伤后病理（例如创伤引起的凝血病）的原因以及潜在的治疗方法。在这篇综述中，我们重点介绍了目前已知的 EV 在创伤各个方面的作用和影响，并探索了已经开始使用 EV 来治疗改变创伤性损伤的生理学和病理学的研究人员的最新文献。使用电动汽车治疗创伤的潜在有效性得到了大量实验研究的支持，但在我们了解电动汽车在已经很复杂的疾病过程中的复杂影响之前，还有很长的路要走。

更新日期：2021-09-17

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