Objective: To investigate the predictors of acute cardiovascular events within 90 days after an acute lower respiratory tract infection (ALRTI) in elderly patients with stable coronary artery disease (sCAD).

Methods: Observational analyses were conducted in a prospective cohort of the elderly with sCAD, during 90 days after they were hospitalized for ALRTI. Multiple logistic regression analysis was performed to identify predictors for acute cardiovascular events and all-cause mortality.

Results: The present study comprised 426 patients with sCAD (median age: 88 years; IQR: 84–91; range: 72–102). Among these patients, 257 suffering from ALRTI were enrolled in the infection group. Meanwhile, 169 patients who did not suffer from ALRTI were regarded as the non-infection group. Compared with the non-infection group, patients in the infection group had a higher incidence of acute cardiovascular events (31.9 vs. 13.6%, p < 0.001) and all-cause mortality (13.2 vs. 1.8%, p < 0.001) during the 90-day follow-up. In addition, in the infection group, the incidence of cardiovascular events was also higher than those in the non-infection group during the 7-day and 30-day follow-up (10.9 vs. 2.4%, p = 0.001; 20.6 vs. 6.5%, p < 0.001). The same difference in the incidence of all-cause mortality during 7 and 30 days (1.2 vs. 0%, p = 0.028; 3.9 vs. 0.6%, p = 0.021) was observed between the two groups. Furthermore, multiple regression analysis found that ALRTI was independently associated with increased risk of cardiovascular events and all-cause mortality in elderly patients with sCAD.

Conclusion: In elderly patients with sCAD, ALRTI was an independent predictor for both cardiovascular events and all-cause mortality.

客观的： 研究老年稳定性冠状动脉疾病 (sCAD) 患者急性下呼吸道感染 (ALRTI) 后 90 天内发生急性心血管事件的预测因素。

方法：在 sCAD 老年人住院 90 天后的前瞻性队列中进行了观察性分析。进行多元逻辑回归分析以确定急性心血管事件和全因死亡率的预测因子。

结果：本研究包括 426 名 sCAD 患者（中位年龄：88 岁；IQR：84-91；范围：72-102）。在这些患者中，257 名患有 ALRTI 的患者被纳入感染组。同时，169 名未患 ALRTI 的患者被视为非感染组。与非感染组相比，感染组患者的急性心血管事件发生率更高（31.9% vs. 13.6%，磷 < 0.001) 和全因死亡率（13.2 对 1.8%， 磷< 0.001) 在 90 天的随访期间。此外，在7天和30天的随访中，感染组心血管事件的发生率也高于非感染组（10.9% vs. 2.4%，磷= 0.001; 20.6 对 6.5%，磷< 0.001)。7 天和 30 天期间全因死亡率发生率的差异相同（1.2 对 0%，磷= 0.028; 3.9 对 0.6%，磷= 0.021) 在两组之间观察到。此外，多元回归分析发现，ALRTI 与老年 sCAD 患者的心血管事件风险和全因死亡率增加独立相关。

结论： 在老年 sCAD 患者中，ALRTI 是心血管事件和全因死亡率的独立预测因子。