Introduction: Alzheimer’s disease (AD) is the most frequently occurring neurodegenerative disease; however, little work has been conducted examining biomarkers of AD among Mexican Americans. Here, we examined diffusion tensor MRI marker profiles for detecting mild cognitive impairment (MCI) and dementia in a multi-ethnic cohort. Methods: 3T MRI measures of fractional anisotropy (FA) were examined among 1,636 participants of the ongoing community-based Health amp; Aging Brain among Latino Elders (HABLE) community-based study (Mexican American n = 851; non-Hispanic white n = 785). Results: The FA profile was highly accurate in detecting both MCI (area under the receiver operating characteristic curve [AUC] = 0.99) and dementia (AUC = 0.98). However, the FA profile varied significantly not only between diagnostic groups but also between Mexican Americans and non-Hispanic whites. Conclusion: Findings suggest that diffusion tensor imaging markers may have a role in the neurodiagnostic process for detecting MCI and dementia among diverse populations.
Dement Geriatr Cogn Disord

中文翻译：

---

使用分数各向异性成像检测墨西哥裔美国人和非西班牙裔白人的轻度认知障碍和阿尔茨海默病：一项 HABLE 研究

简介：阿尔茨海默病 (AD) 是最常见的神经退行性疾病；然而，很少有研究检查墨西哥裔美国人的 AD 生物标志物。在这里，我们检查了扩散张量 MRI 标记图谱，用于检测多种族队列中的轻度认知障碍 (MCI) 和痴呆症。方法：在正在进行的以社区为基础的 Health amp; 的 1,636 名参与者中检查分数各向异性 (FA) 的 3T MRI 测量值。拉丁裔老年人大脑老化 (HABLE) 基于社区的研究（墨西哥裔美国人n = 851；非西班牙裔白人n = 785）。结果：FA 配置文件在检测 MCI（接受者操作特征曲线下面积 [AUC] = 0.99）和痴呆症（AUC = 0.98）方面非常准确。然而，FA 概况不仅在诊断组之间存在显着差异，而且在墨西哥裔美国人和非西班牙裔白人之间也存在显着差异。结论：研究结果表明，弥散张量成像标记物可能在神经诊断过程中发挥作用，用于检测不同人群中的 MCI 和痴呆症。
老年痴呆症认知障碍