The interactions of diglycine with sulphathiazole drug as a function of temperatures have been studied using volumetric and acoustic parameters. Densities and speeds of sound of diglycine in (0.001, 0.002, 0.005 and 0.010) mol·kg^-1 aqueous solutions of sulphathiazole drug have been measured at five different temperatures of (288.15, 293.15, 298.15, 303.15 and 308.15) K under 0.1 MPa pressure. From density data, the apparent molar volume, the partial molar volume and the standard partial molar volume of transfer for glycine from water to aqueous sulphathiazole solutions have been calculated. Partial molar isentropic compression and partial molar isentropic compression of transfer have been calculated from the speed of sound data. Transfer parameters by using cosphere overlap model have been explained on the basis of ionic-hydrophilic, hydrophilic-hydrophilic, hydrophilic-hydrophobic and hydrophobic-hydrophobic group interactions. To draw the conclusion from the volumetric and acoustic data, limiting apparent molar expansion as well as the hydration numbers have been studied. The calculated values of thermal expansion coefficient have small and positive values. All of these derived or calculated parameters are explained to understand the solvation behaviour and various types of interactions born in the ternary solutions of (dipeptide + drug + water) due to change in structure. We have also attempted to examine the temperature and concentration dependence of such interactions.

中文翻译：

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双甘氨酸与磺胺噻唑药物水溶液在不同温度下的相互作用研究

已经使用体积和声学参数研究了双甘氨酸与磺胺噻唑药物作为温度函数的相互作用。二甘氨酸在 (0.001, 0.002, 0.005 和 0.010) mol·kg ^{-1 中的}密度和声速在 0.1 MPa 压力下，在五种不同温度（288.15、293.15、298.15、303.15 和 308.15）K 下测量了磺胺噻唑药物的水溶液。根据密度数据，已经计算出甘氨酸从水中转移到磺胺噻唑水溶液的表观摩尔体积、偏摩尔体积和标准偏摩尔体积。转移的偏摩尔等熵压缩和偏摩尔等熵压缩已经从声速数据计算出来。基于离子-亲水、亲水-亲水、亲水-疏水和疏水-疏水基团相互作用解释了使用共球重叠模型的转移参数。为了从体积和声学数据得出结论，已经研究了限制表观摩尔膨胀以及水合数。热膨胀系数的计算值有小而正的值。解释所有这些导出或计算的参数，以了解由于结构变化而在（二肽 + 药物 + 水）三元溶液中产生的溶剂化行为和各种类型的相互作用。我们还试图检查这种相互作用的温度和浓度依赖性。