Tetrahydrocarbazoles (THC) is a privileged structural scaffold containing natural indole as the central moiety. This extraordinary skeleton features in a plethora of naturally occurring pharmacological compounds and alkaloids exhibiting a significant inhibitory activity such as antibacterial, protein kinase inhibitor, and tumor growth inhibitor, etc. Due to its versatile biological properties, it always gains considerable attention among the scientific community. The main objective of this review is to make a comprehensive reference work on the synthesis and biological properties of THCs, thus targeting a broad audience on the assessment of various catalysts along with their reaction condition, mechanism of action, and yield, which are categorized into three groups: 1) organocatalyzed reactions; 2) TfOH catalyzed reactions; 3) metal-catalyzed reactions and 4) miscellaneous.

四氢咔唑 (THC) 是一种特殊的结构支架，含有天然吲哚作为中心部分。这种非凡的骨架以大量天然存在的药理化合物和生物碱为特征，表现出显着的抑制活性，如抗菌、蛋白激酶抑制剂和肿瘤生长抑制剂等。 由于其多功能的生物学特性，它一直受到科学界的广泛关注. 本综述的主要目的是对 THCs 的合成和生物学特性进行全面的参考工作，从而针对各种催化剂及其反应条件、作用机制和产率的评估，将其分为以下几类：三组：1）有机催化反应；2) TfOH催化反应；