New drugs introduced in the market each year, have privileged structures specifically for anticancer targets, of which quinoline-based analogues also play an important role. This review highlights quinoline and its derivatives, which have great potency against various cancer cells, including prostate cancer, breast cancer, colon cancer, pancreas cancer, and many more. This review describes the most preferred process-scale synthetic approaches of quinoline and its derivatives having a specific pharmacophore for anticancer targets. It also describes the undergoing development and recently approved drugs in tabular form. Quinoline moiety as a privileged structural pharmacophore has the most effective activity against different cancer cell lines like prostate cancer, breast cancer, stomach cancer, pancreas cancer, Colon cancer, CNS cancer, and renal cancer. It can be used as a lead compound for further research on anticancer drug discovery.

每年上市的新药都有专门针对抗癌靶点的特权结构，其中喹啉类似物也发挥着重要作用。这篇综述重点介绍了喹啉及其衍生物，它们对多种癌细胞具有强大的杀伤力，包括前列腺癌、乳腺癌、结肠癌、胰腺癌等等。本综述描述了喹啉及其衍生物的最优选的工艺规模合成方法，该方法具有抗癌靶标的特定药效团。它还以表格形式描述了正在进行的开发和最近批准的药物。喹啉部分作为一种特殊的结构药效团，对不同的癌细胞系具有最有效的活性，如前列腺癌、乳腺癌、胃癌、胰腺癌、结肠癌、中枢神经系统癌、和肾癌。它可以作为先导化合物用于进一步研究抗癌药物的发现。