Benzoxazole compounds have an important and broad range of biological activities. The benzoxazole and its substituted derivatives possess antimicrobial, antitumor, anti-inflammatory, antihistaminic, anti-parasitic, herbicidal, anti-allergic, anti-helmintic, anti-tubercular, anticonvulsant, hypoglycaemic, HIV-1 reverse transcriptase inhibitor and insecticidal activities. It has also been shown to have a binding affinity to Aβ42 fibrils. Such complex biological uses of benzoxazole compounds have inspired new efforts to find new derivatives with improved biological activity and different applications in the pharmaceutical industry. Due to outstanding relevance of this structure, the purpose of this analysis is to highlight aspects published in recent years (2000-2020) on the chemistry and biological activity of benzoxazoles.

苯并恶唑化合物具有重要而广泛的生物活性。苯并恶唑及其取代衍生物具有抗菌、抗肿瘤、抗炎、抗组胺、抗寄生虫、除草、抗过敏、抗蠕虫、抗结核、抗惊厥、降血糖、HIV-1逆转录酶抑制剂和杀虫活性。它还被证明对 Aβ42 原纤维具有结合亲和力。苯并恶唑化合物的这种复杂的生物学用途激发了新的努力，以寻找具有改善的生物活性和在制药工业中的不同应用的新衍生物。由于这种结构的突出相关性，本分析的目的是强调近年来（2000-2020 年）发表的关于苯并恶唑的化学和生物活性的方面。