One way to enhance the poor mechanical properties of the self-healing hydrogels based on host-guest (HG) interaction is employing the dual cross-linking method. Here, the alginate-based hydrogels based on HG complexation were prepared through the modification of alginate (ALG) polysaccharide with beta-cyclodextrin (βCD) and adamantane (Ad) as host and guest groups with different grafting values, respectively. The porous structure was confirmed for all ALG-CD:ALG-Ad hydrogels. The average pore size of ALG-CD₁:ALG-Ad₁ hydrogel cross-linked by HG interactions was 288 μm. Mechanical properties of the alginate-based HG hydrogels were improved by incorporating Ca²⁺ ions in their structure through dual cross-linking methodology. The maximum modulus of the porous dual-crosslinked hydrogel was reached up to 6500 Pa. The healing time of less than 5 s was obtained for the alginate-based hydrogels. The fabricated hydrogels can be used in 3D printing, tissue engineering, and drug delivery systems due to their biocompatibility and shear-thinning behavior.

一种增强基于主客体 (HG) 相互作用的自修复水凝胶机械性能差的方法是采用双交联方法。在这里，通过分别以β-环糊精（βCD）和金刚烷（Ad）为主体和客体的不同接枝值的海藻酸盐（ALG）多糖改性，制备了基于HG络合的海藻酸盐基水凝胶。所有 ALG-CD:ALG-Ad 水凝胶均具有多孔结构。通过 HG 相互作用交联的 ALG-CD ₁ :ALG-Ad ₁水凝胶的平均孔径为 288 μm。通过掺入 Ca ²⁺改善了基于藻酸盐的 HG 水凝胶的机械性能通过双交联方法在其结构中分离离子。多孔双交联水凝胶的最大模量达到 6500 Pa。海藻酸盐基水凝胶的愈合时间小于 5 秒。由于其生物相容性和剪切稀化行为，制造的水凝胶可用于 3D 打印、组织工程和药物输送系统。