Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles,Chemical Society Reviews

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Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2021-09-17 , DOI: 10.1039/d0cs00031k
Darren M Griffith _{1,

2} , Hongyan Li ₃ , Melissa V Werrett ₄ , Philip C Andrews ₄ , Hongzhe Sun ₃

Affiliation

Bismuth as a relatively non-toxic and inexpensive metal with exceptional properties has numerous biomedical applications. Bismuth-based compounds are used extensively as medicines for the treatment of gastrointestinal disorders including dyspepsia, gastric ulcers and H. pylori infections. Recently, its medicinal application was further extended to potential treatments of viral infection, multidrug resistant microbial infections, cancer and also imaging, drug delivery and biosensing. In this review we have highlighted the unique chemistry and biological chemistry of bismuth-209 as a prelude to sections covering the unique antibacterial activity of bismuth including a description of research undertaken to date to elucidate key molecular mechanisms of action against H. pylori, the development of novel compounds to treat infection from microbes beyond H. pylori and the significant role bismuth compounds can play as resistance breakers. Furthermore we have provided an account of the potential therapeutic application of bismuth-213 in targeted alpha therapy as well as a summary of the biomedical applications of bismuth-based nanoparticles and composites. Ultimately this review aims to provide the state of the art, highlight the untapped biomedical potential of bismuth and encourage original contributions to this exciting and important field.

中文翻译：

铋基化合物和纳米粒子的药物化学和生物医学应用

铋作为一种相对无毒且价格低廉的金属，具有优异的性能，具有许多生物医学应用。铋基化合物广泛用作治疗胃肠道疾病的药物，包括消化不良、胃溃疡和幽门螺杆菌感染。最近，它的医学应用进一步扩展到病毒感染、多重耐药微生物感染、癌症以及成像、药物递送和生物传感的潜在治疗。在这篇综述中，我们重点介绍了铋 209 的独特化学和生物化学，作为介绍铋独特抗菌活性的部分的前奏，包括描述迄今为止为阐明针对幽门螺杆菌的关键作用分子机制而进行的研究，用于治疗幽门螺杆菌以外的微生物感染的新型化合物的开发以及铋化合物作为抗药性破坏剂的重要作用。此外，我们还介绍了 bismuth-213 在靶向 α 疗法中的潜在治疗应用，以及基于铋的纳米颗粒和复合材料的生物医学应用的总结。最终，这篇综述旨在提供最先进的技术，突出铋尚未开发的生物医学潜力，并鼓励对这一激动人心且重要的领域做出原创性贡献。

更新日期：2021-09-17

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