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Synthesis of axially chiral biaryl thioglycosides through thiosugar-directed Pd-catalyzed asymmetric C–H activation
Chemical Communications ( IF 4.3 ) Pub Date : 2021-09-13 , DOI: 10.1039/d1cc03971g
Maha Fatthalla 1, 2 , Nicolas Grimblat 3, 4 , Etienne Brachet 5 , Mouad Alami 2 , Vincent Gandon 3, 6 , Franck Le Bideau 2 , Samir Messaoudi 2
Affiliation  

Herein we report for the first time that the thiosugar moiety can be used both as a directing group enabling the regioselective activation of a C–H bond of biaryl scaffolds and as a chiral source inducing axial chirality. Our approach enables the easy generation of complex thioglycoside atropoisomers, thus paving the way to new products of potential biological interest.

中文翻译:

通过硫糖导向的 Pd 催化不对称 C-H 活化合成轴向手性联芳硫糖苷

在此,我们首次报告硫糖部分既可用作导向基团,使联芳支架的 C-H 键区域选择性活化,也可用作诱导轴向手性的手性源。我们的方法可以轻松生成复杂的硫糖苷阻转异构体,从而为开发具有潜在生物学意义的新产品铺平道路。
更新日期:2021-09-17
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