Intelligent Design of Ultrasmall Iron Oxide Nanoparticle-Based Theranostics,ACS Applied Materials & Interfaces

当前位置： X-MOL 学术 › ACS Appl. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Intelligent Design of Ultrasmall Iron Oxide Nanoparticle-Based Theranostics
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-09-17 , DOI: 10.1021/acsami.1c13341
Yue Gao ₁ , Xiangyang Shi ₁ , Mingwu Shen ₁

Affiliation

Rapid advances in nanotechnology have opened up innovative trails to break through the current limitation in clinical treatments of cancer and other critical diseases that plague human beings. Ultrasmall iron oxide nanoparticles (USIO NPs) with sizes smaller than 5 nm have been emerging as a novel category of nanomaterials with increasing interest in the biomedical domains. To overcome their intrinsic shortcomings, naked USIO NPs can be functionalized, clustered, assembled, or incorporated with other nanomaterials to generate various kinds of intelligent nanoplatforms for single-mode or dynamic magnetic resonance (MR) imaging, multimode imaging, as well as imaging-guided precision therapy. In this spotlight on applications, first, we propose the principal aspects in the design and application of USIO NPs for biomedical uses. Second, we cover the recent design strategies of USIO NP-based nanoplatforms mainly developed by our group, describe the rationale on the combination of other functional materials with USIO NPs, and review their resultant applications in theranostics. In addition, we provide herein a perspective on the possible future directions toward USIO NP-based nanoplatforms as smart nanomedicines.

中文翻译：

超小氧化铁纳米粒子治疗学的智能设计

纳米技术的快速发展开辟了创新途径，以突破目前在癌症和其他困扰人类的重大疾病的临床治疗方面的限制。尺寸小于 5 nm 的超小氧化铁纳米粒子 (USIO NPs) 已成为一种新型纳米材料，在生物医学领域的兴趣日益浓厚。为了克服它们固有的缺点，裸 USIO NPs 可以被功能化、聚集、组装或与其他纳米材料结合，以生成各种智能纳米平台，用于单模或动态磁共振 (MR) 成像、多模成像以及成像-引导精准治疗。在这个关于应用的聚光灯下，首先，我们提出了用于生物医学用途的 USIO NP 的设计和应用的主要方面。第二，我们涵盖了主要由我们小组开发的基于 USIO NP 的纳米平台的最新设计策略，描述了其他功能材料与 USIO NP 组合的基本原理，并回顾了它们在治疗学中的应用。此外，我们在此提供了关于将基于 USIO NP 的纳米平台作为智能纳米药物的未来可能方向的观点。

更新日期：2021-09-29

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11