A series of glycyrrhetinic acid, oleanolic acid and ursolic acid derivatives were designed and synthesized. Structures of all novel compounds were determined by ¹H NMR, ¹³C NMR, and HRMS methods. In vitro anti-proliferative effects of all compounds were evaluated against A549, Hela and HepG2 cancer cell lines. The three compounds G2, G3 and G4 showed better anti-proliferative effects than the positive control doxorubicin on the three kinds of cancer cells. The two compounds O1 and U11 showed better anti-proliferative effects than doxorubicin on Hela cells. The four compounds O2, O3, O8 and U8 showed better anti-proliferative effects than doxorubicin on HepG2 cells. Notably, compound G3 demonstrated the strongest growth inhibitory effects with IC₅₀ values of 0.16 ± 0.23 µM and 0.33 ± 0.41 µM on Hela and HepG2 cells, respectively, and compound G2 demonstrated the strongest growth inhibitory effect with IC₅₀ values of 0.80 ± 1.03 µM on A549 cells.

设计合成了一系列甘草次酸、齐墩果酸和熊果酸衍生物。所有新化合物的结构均通过¹ H NMR、¹³ C NMR 和 HRMS 方法确定。评估了所有化合物对 A549、Hela 和 HepG2 癌细胞系的体外抗增殖作用。三种化合物G2、G3和G4对三种癌细胞显示出比阳性对照阿霉素更好的抗增殖作用。两种化合物O1和U11对Hela细胞显示出比阿霉素更好的抗增殖作用。四种化合物O2 , O3 , O8和U8表现出比对HepG2细胞阿霉素更好的抗增殖作用。值得注意的是，化合物G3对 Hela 和 HepG2 细胞的生长抑制作用最强，IC ₅₀值分别为 0.16 ± 0.23 µM 和 0.33 ± 0.41 µM，化合物G2的生长抑制作用最强，IC ₅₀值为 0.80 ± 1.03 µM在 A549 细胞上。