Preparation and Characterization of the Molybdenum Disulfide Nanosheets Coated with Poly-(NVCL-co-AGE))/MA for the Anticancer Drug Delivery Light,ChemistrySelect

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Preparation and Characterization of the Molybdenum Disulfide Nanosheets Coated with Poly-(NVCL-co-AGE))/MA for the Anticancer Drug Delivery Light
ChemistrySelect ( IF 1.9 ) Pub Date : 2021-09-17 , DOI: 10.1002/slct.202102401
Mina Mohammadi Kalakoo ₁ , Amir Heydarinasab ₁ , Elham Moniri ₂ , Homayon Ahmad Panahi ₃ , Rabea Khoshneviszadeh ₄

Affiliation

A novel thermosensitive polymer (poly-(NVCL-co-AGE))/MA was synthesized by N-vinylcaprolactam (NVCL), 5-Amino-2-hydroxybenzoic acid (Mesalamine, MA) and allyl glycidyl ether (AGE). The obtained polymeric matrix is functionalized on molybdenum disulfide nanosheets (MNs (which is used as a drug carrier for efficient drug delivery. The ability of MNs - (poly-(NVCL-co-AGE))/MA was estimated as a nanocarrier for the delivery of imatinib mesylate (IM) as an antitumor drug. The resulting polymer was confirmed by FESEM/EDX, TEM, XRD, FTIR, TGA, and UV-Vis spectroscopy. The impacts of various variables such as pH, contact time, and temperature on the adsorption efficiency were also evaluated. Kinetic and isotherm studies of IM adsorption demonstrated that the adsorption of IM on the surface of MNs - (poly-(NVCL-co-AGE))/MA was well fitted to the pseudo-second-order kinetic and Langmuir isotherm models, respectively. On the other hand, we were interested in estimating drug release kinetics and in vitro release behavior of IM loaded on MNs - (poly-(NVCL-co-AGE))/MA. In vitro controlled drug release and phototherapy under near-infrared (NIR) light irradiation are also discussed. The existence of absorbed NIR energy causes shrinkage of thermo-sensitive polymer chains and successfully caused the drug release. In vitro drug release of MNs - (poly-(NVCL-co-AGE))/MA was comparatively carried out at 37 and 50 °C. The release rate of MNs - (poly-(NVCL-co-AGE))/MA at 50 °C was much higher than those at 37 °C. Also, the drug release behavior after the involvement of NIR light irradiation reached up to 98 % over 15 min, which was about 11 times that without NIR light irradiation.

中文翻译：

用于抗癌药物传递光的聚-(NVCL-co-AGE))/MA 包覆的二硫化钼纳米片的制备和表征

由 N-乙烯基己内酰胺 (NVCL)、5-氨基-2-羟基苯甲酸 (Mesalamine, MA) 和烯丙基缩水甘油醚 (AGE) 合成了一种新型热敏聚合物 (poly-(NVCL-co-AGE))/MA。获得的聚合物基质在二硫化钼纳米片（MNs（用作有效药物递送的药物载体）上官能化。MNs -（聚（NVCL-co-AGE））/MA的能力被估计为纳米载体递送甲磺酸伊马替尼 (IM) 作为抗肿瘤药物。所得聚合物通过 FESEM/EDX、TEM、XRD、FTIR、TGA 和 UV-Vis 光谱证实。各种变量的影响，如 pH、接触时间和温度对吸附效率也进行了评价。IM 吸附的动力学和等温线研究表明，IM 在 MNs 表面的吸附 - (poly-(NVCL-co-AGE))/MA 分别适合伪二级动力学和 Langmuir 等温线模型。另一方面，我们感兴趣的是估计负载在 MN 上的 IM 的药物释放动力学和体外释放行为 - (poly-(NVCL-co-AGE))/MA。还讨论了在近红外 (NIR) 光照射下的体外受控药物释放和光疗。吸收的 NIR 能量的存在导致热敏聚合物链收缩并成功导致药物释放。MNs - (poly-(NVCL-co-AGE))/MA 的体外药物释放是在 37 和 50 °C 下进行的。MNs - (poly-(NVCL-co-AGE))/MA 在 50 °C 下的释放率远高于 37 °C。还，

更新日期：2021-09-17

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