Acetylated Rhamnose Triterpenoid Saponins from Glechoma longituba Analyzed by LC-Q-TOFMS,Chemistry & Biodiversity

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Acetylated Rhamnose Triterpenoid Saponins from Glechoma longituba Analyzed by LC-Q-TOFMS
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2021-09-16 , DOI: 10.1002/cbdv.202100272
Xi-Lin Ouyang _{1,

2} , Tian-Hua Ma ₃ , Gui-Liang Xie ₂ , Shan Chen ₄ , Heng-Shan Wang ₁ , Qiang Jia ₃ , En-De Zhang ₄ , Jing-Hua Huang ₄

Affiliation

The aim of the present work is to isolate a series of triterpene derivatives with rhamnosyl linking acetyl groups from Glechoma longituba according to the structural characteristics of previously described triterpene saponins. The extract ion chromatography spectrum of the crude extract of G. longituba was detected and analyzed by HPLC-HR-ESI-MS to determine possible components, and these metabolites were traced and separated by combining high-resolution mass spectrometry and predicted liquid chromatography retention time. Three 11α, 12α-epoxypentacyclic oleanolic acid triterpene saponins (glechomanosides H–J) and one ursane triterpene aldehyde saponin with a C-28 aldehyde group were isolated from G. longituba. The structure of these compounds was confirmed by NMR and compared with those of previously characterized compounds. The strategy described in this report enables a rapid, reliable, and complete analysis of glycoside compounds containing different numbers of acetyl groups at different positions on the sugar.

中文翻译：

LC-Q-TOFMS法分析长叶毛茛乙酰化鼠李糖三萜皂苷

本工作的目的是从隔离与鼠李糖联乙酰基的一系列三萜衍生物的欧亚活血丹长筒根据先前描述三萜皂甙的结构特性。采用 HPLC-HR-ESI-MS 对长叶茯苓粗提物的提取物离子色谱图谱进行检测和分析，以确定可能的成分，并结合高分辨质谱和预测液相色谱保留时间对这些代谢物进行追踪和分离. 从G. longituba中分离出三种 11α, 12α-环氧五环齐墩果酸三萜皂苷 (glechomanosides H-J) 和一种具有 C-28 醛基的熊果苷三萜醛皂苷. 这些化合物的结构通过核磁共振得到证实，并与先前表征的化合物进行了比较。本报告中描述的策略能够对糖上不同位置含有不同数量乙酰基的糖苷化合物进行快速、可靠和完整的分析。

更新日期：2021-11-15

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