This study aimed to compare the pharmacokinetic properties of four preparations (dispersible tablets, ordinary tablets, capsules and granules) of arbidol hydrochloride, a broad-spectrum antiviral drug, in beagle dogs. Briefly, a single dose of 100 mg of the four preparations of arbidol hydrochloride was orally administered to dogs; blood was then collected from the veins of the foreleg at different times after administration to prepare plasma samples. The plasma concentration of arbidol hydrochloride was measured using a validated liquid chromatography–tandem mass spectrometry (LC–MS/MS). The results showed that when orally administered with dispersible tablets, ordinary tablets, capsules and granules suspended with water, there were no significant differences in the pharmacokinetic parameters (including peak time, peak concentration, elimination half-life, area under the curve (AUC_0–t), and mean retention time) of arbidol hydrochloride. However, in the case of the dispersible tablets, the pharmacokinetics of arbidol hydrochloride was significantly affected by the mode of administration. Compared with direct feeding, peak time [0.50 (0.13, 0.50) vs. 1.00 (0.50, 2.00)] was significantly shortened (P = 0.033) and the AUC_{0–48 h} (8726.5 ± 2509.3 vs. 3650.8 ± 1536.9 ng h/ml) was significantly increased (P = 0.012) when the dispersible tablets were orally administered as water dispersion. In conclusion, the pharmacokinetics of four preparations of arbidol hydrochloride were not significant different in beagle dogs. However, compared with direct feeding, the absorption of arbidol hydrochloride was faster and the bioavailability was better when the dispersible tablets were orally administered as water dispersion.

中文翻译：

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四种盐酸阿比朵尔制剂在比格犬体内的药代动力学比较

本研究旨在比较广谱抗病毒药物盐酸阿比朵尔四种制剂（分散片、普通片、胶囊和颗粒）在比格犬体内的药代动力学特性。简而言之，将盐酸阿比朵尔的四种制剂的单剂量100mg口服给予犬；然后在给药后的不同时间从前腿静脉采集血液以制备血浆样品。使用经过验证的液相色谱-串联质谱 (LC-MS/MS) 测量盐酸阿比朵尔的血浆浓度。结果表明，分散片、普通片剂、胶囊剂和水悬浮颗粒剂口服给药时，药动学参数（包括达峰时间、达峰浓度、_{0– t} ) 和平均保留时间) 的盐酸阿比朵尔。然而，在分散片的情况下，阿比朵尔盐酸盐的药代动力学受到给药方式的显着影响。与直接喂食相比，峰值时间 [0.50 (0.13, 0.50) vs. 1.00 (0.50, 2.00)] 显着缩短 ( P  = 0.033) 和 AUC _{0-48 h} (8726.5 ± 2509.3 vs. 3650.8 ± 1536.9 ng h/ ml) 显着增加 ( P = 0.012) 当分散片作为水分散体口服给药时。总之，四种盐酸阿比朵尔制剂的药代动力学在比格犬中没有显着差异。但与直接喂食相比，盐酸阿比朵尔分散片以水分散体形式口服给药时吸收更快，生物利用度更好。