Parahydrogen Hyperpolarization Allows Direct NMR Detection of α-Amino Acids in Complex (Bio)mixtures,Angewandte Chemie International Edition

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Parahydrogen Hyperpolarization Allows Direct NMR Detection of α-Amino Acids in Complex (Bio)mixtures
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-09-17 , DOI: 10.1002/anie.202109588
Lisanne Sellies ₁ , Ruud L E G Aspers ₁ , Martin C Feiters ₁ , Floris P J T Rutjes ₁ , Marco Tessari ₁

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Non-hydrogenative parahydrogen hyperpolarization allows the detection and quantification of α-amino acids down to sub-micromolar concentrations. This method can also be applied to aqueous mixtures after dilution with methanol without any additional sample treatment. This direct approach was tested on human urine, allowing a well-resolved detection of amino acids despite the complexity of the mixture.