Improving wound healing by developing innovative dressing materials has been an important focus over the past few years in the biomedical field. In this regard, the current study focuses on developing new dressings based on acrylate-endcapped urethane-based polymers (AUPs). The materials have been processed into films and electrospun mats. Exudate uptake capacity, mechanical properties and fiber morphology were evaluated herein. The results showed superior uptake capacity of both films and mats when compared to Aquacel®Ag, Exufiber® and Help®. Addition of a high molar mass poly(ethylene glycol) to the AUP polymers benefits both the film and electrospun dressings in terms of flexibility and elongation. An in vivo study was conducted to assess the wound healing properties of these dressings on an acute wound model induced to rats. A macroscopic evaluation indicated that wound contraction and wound fraction percentages were improved significantly in case of the AUP-materials when compared to both the positive (Aquacel®Ag) and negative (Exufiber® and Help®) controls. A histopathological assay, to underline the changes noticed on a macroscopical level, was also performed. The data obtained proved that the developed dressings are beneficial towards tissue regeneration and accelerated wound healing. These findings offer a practical yet adequate strategy for the fabrication of acrylate-endcapped urethane-based materials for wound healing applications.

通过开发创新的敷料材料来改善伤口愈合是过去几年生物医学领域的一个重要焦点。在这方面，目前的研究重点是开发基于丙烯酸酯封端的氨基甲酸酯基聚合物 (AUP) 的新型敷料。这些材料已被加工成薄膜和电纺毡。在此评估渗出液吸收能力、机械性能和纤维形态。结果表明，与 Aquacel®Ag、Exufiber® 和 Help® 相比，薄膜和垫子的吸收能力都更高。将高摩尔质量的聚（乙二醇）添加到 AUP 聚合物中，在柔韧性和伸长率方面对薄膜和电纺敷料都有好处。一个在体内进行了研究以评估这些敷料在诱导大鼠的急性伤口模型上的伤口愈合特性。宏观评估表明，与阳性 (Aquacel®Ag) 和阴性 (Exufiber® 和 Help®) 对照相比，AUP 材料的伤口收缩和伤口分数百分比显着改善。还进行了组织病理学分析，以强调在宏观水平上注意到的变化。获得的数据证明，所开发的敷料有利于组织再生和加速伤口愈合。这些发现为制备用于伤口愈合应用的丙烯酸酯封端的氨基甲酸酯基材料提供了一种实用但足够的策略。