Recently, great attention has been paid to hydroxychloroquine which after promising in vitro studies has been proposed to treat the severe acute respiratory syndrome caused by SARS-CoV-2. The clinical trials have shown that hydroxychloroquine was not as effective as was expected and additionally, several side effects were observed in patients cured with this medicament. In order to reduce them, it is suggested to deliver hydroxychloroquine in a controlled manner. Therefore, in this study non-modified (SBA-15, SBA-16) and modified with copper and aminosilane mesoporous silica materials were applied as novel nanocarriers for hydroxychloroquine. First, pristine and functionalized samples were synthesized and characterized by X-ray diffraction, low-temperature nitrogen sorption, transmission electron microscopy, X-ray photoelectron spectroscopy, infrared spectroscopy, laser diffraction. Then the influence of physicochemical parameters of materials obtained on the adsorption and release processes of hydroxychloroquine was analyzed. The mechanism of hydroxychloroquine binding to non-modified silicas was based on the formation of hydrogen bonds, while in the case of copper and aminosilane functionalized materials the complexes with drug molecules were generated. The release behavior of hydroxychloroquine from silica samples obtained was determined by different factors including pH conditions, textural parameters, surface charge, and presence of surface functional groups. The greatest differences in hydroxychloroquine release profiles between materials were observed at pH 7.2. The amount of drug desorbed from silica decreased in the following order: functionalized SBA-15 (84%) > functionalized SBA-16 (79%) > SBA-15 (59%) > SBA-16 (33%). It proved that a higher amount of drug was released from materials of hexagonal structure.

近来备受关注的是羟氯喹，它在体外应用前景看好后已经提出研究来治疗由 SARS-CoV-2 引起的严重急性呼吸系统综合症。临床试验表明，羟氯喹没有预期的那么有效，此外，在用这种药物治愈的患者中观察到一些副作用。为了减少它们，建议以可控的方式输送羟氯喹。因此，在本研究中，未改性（SBA-15、SBA-16）和用铜和氨基硅烷改性的介孔二氧化硅材料被用作羟氯喹的新型纳米载体。首先，合成了原始和功能化样品，并通过 X 射线衍射、低温氮吸附、透射电子显微镜、X 射线光电子能谱、红外光谱、激光衍射对其进行了表征。然后分析了所得材料的理化参数对羟氯喹吸附和释放过程的影响。羟氯喹与未改性二氧化硅结合的机制基于氢键的形成，而在铜和氨基硅烷功能化材料的情况下，会生成与药物分子的复合物。羟基氯喹从二氧化硅样品中的释放行为取决于不同的因素，包括 pH 条件、结构参数、表面电荷和表面官能团的存在。在 pH 7.2 时观察到材料之间羟氯喹释放曲线的最大差异。从硅胶上解吸的药物量按以下顺序减少：功能化 SBA-15 (84%) > 功能化 SBA-16 (79%) > SBA-15 (59%) > SBA-16 (33%)。证明六方结构的材料释放出更多的药物。