Microcystis aeruginosa produces an abundant cyanotoxin (microcystins (MCs) in freshwater supplies. MCs have adverse health hazards to animals and humans. Microcystin-leucine-arginine (microcystin-LR or MC-LR) is the most studied among these MCs due to their high toxicity. So, this study was designed to evaluate the possible therapeutic role of the natural algal food supplement, Spirulina platensis (SP), against MC-LR-induced toxic effects in male Wistar rats. Forty rats were randomly divided into five groups. Control and SP groups orally administered distilled water and SP (1000 mg/kg/daily), respectively, for 21 days. MC-LR group was intraperitoneally injected with MC-LR (10 μg/kg/day) for 14 days. MC-LR-SP₅₀₀ and MC-LR-SP₁₀₀₀ groups were orally treated with SP (500 and 1000 mg/kg, respectively) for 7 days and concomitantly with MC-LR for 14 days. MC-LR induced oxidative hepatorenal damage, cardiotoxicity, and neurotoxicity greatly, which was represented by reduction of reduced glutathione content and the activities of glutathione peroxidase, catalase, and superoxide dismutase and elevation of concentrations of nitric oxide and malondialdehyde in renal, hepatic, brain, and heart tissues. In addition, it increased serum levels of urea, creatinine, tumor necrosis factor-alfa, interleukin-1beta and interleukin-6 and serum activities of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, creatine kinase, and creatine kinase-MB. However, S. platensis restored normal levels of measured serum parameters, ameliorated MC-LR-induced oxidative damage, and normalized tissue antioxidant biomarkers. In conclusion, SP alleviated MC-induced organ toxicities by mitigating oxidative and nitrosative stress and lipid peroxidation.

铜绿微囊藻在淡水供应中产生大量的蓝藻毒素（微囊藻毒素 (MCs)）。MCs 对动物和人类有不利的健康危害。微囊藻毒素-亮氨酸-精氨酸（微囊藻毒素-LR 或 MC-LR）是这些 MCs 中研究最多的，因为它们的高毒性。因此，本研究旨在评估天然藻类食品补充剂钝顶螺旋藻(SP) 对 MC-LR 诱导的雄性 Wistar 大鼠毒性作用的可能治疗作用。将 40 只大鼠随机分为五组。对照和SP组分别口服蒸馏水和SP（1000 mg/kg/d），连续21天。MC-LR组腹腔注射MC-LR（10 μg/kg/天），连续14天。 -SP ₅₀₀和 MC-LR-SP ₁₀₀₀各组口服 SP（分别为 500 和 1000 mg/kg）7 天，同时口服 MC-LR 14 天。MC-LR可引起严重的氧化性肝肾损伤、心脏毒性和神经毒性，表现为还原型谷胱甘肽含量降低，谷胱甘肽过氧化物酶、过氧化氢酶和超氧化物歧化酶活性降低，肾、肝、脑一氧化氮和丙二醛浓度升高和心脏组织。此外，它还增加了尿素、肌酐、肿瘤坏死因子-α、白细胞介素-1β 和白细胞介素-6 的血清水平以及碱性磷酸酶、天冬氨酸氨基转移酶、丙氨酸氨基转移酶、乳酸脱氢酶、肌酸激酶和肌酸激酶-MB 的血清活性。然而，S. platensis恢复正常水平的测量血清参数，改善 MC-LR 诱导的氧化损伤，并使组织抗氧化生物标志物正常化。总之，SP 通过减轻氧化应激和亚硝化应激以及脂质过氧化作用来减轻 MC 诱导的器官毒性。