Versatile nano-theranostic agents are highly desirable for the precision nanomedicine of tumors in recent years. In this work, a multifunctional diagnostic and therapeutic agent Bi₂S₃-MnO₂@BSA-Ce6 (BMBC) was successfully prepared by a combination strategy of facile chemical coupling and biomineralization under mild conditions. These BMBC nanoparticles with an average diameter of 17.6 ± 4.6 nm exhibited favorable physiological stability and negligible toxicity. This agent expressed outstanding performance of photothermal conversion (η = 45.8%) under 808 nm laser radiation and generation of ¹O₂ under 650 nm laser irradiation. Due to the strong X-ray attenuation performance of element Bi and the highly effective magnetic moment of Mn²⁺, this agent exhibited favorable performance of X-ray computed tomography (CT) imaging (35.60 HU•mL•mg⁻¹) and magnetic resonance (MR) imaging (r₁ = 5.22 mM⁻¹•s⁻¹) in vitro. Furthermore, most of the HeLa cells treated with BMBC NPs were dead in the MTT and Calcein-AM/PI staining experiments, demonstrating the excellent effect of intracellular synergistic therapy. Overall, this theranostic agent could serve as a promising nano-platform for photothermal/photodynamic synergistic therapy of tumors under the guidance of infrared thermal (IRT)/MR/CT imaging.

近年来，多功能纳米治疗药物对于肿瘤的精确纳米医学非常需要。在这项工作中，通过温和的化学偶联和生物矿化的组合策略，成功制备了多功能诊断和治疗剂 Bi ₂ S ₃ -MnO ₂ @BSA-Ce6 (BMBC)。这些平均直径为 17.6 ± 4.6 nm 的 BMBC 纳米粒子表现出良好的生理稳定性和可忽略的毒性。该试剂在 808 nm 激光辐射下表现出优异的光热转换性能（η = 45.8%）并产生¹ O ₂在 650 nm 激光照射下。由于Bi元素强大的X射线衰减性能和Mn ^{2+ 的}高效磁矩，该试剂表现出良好的X射线计算机断层扫描（CT）成像（35.60 HU•mL•mg ^-1）和磁性能。体外共振（MR）成像（r ₁  = 5.22 mM ^-1 •s ^-1）。此外，大多数用 BMBC NPs 处理的 HeLa 细胞在 MTT 和 Calcein-AM/PI 染色实验中死亡，证明了细胞内协同治疗的优异效果。总的来说，这种治疗诊断剂可以作为一个有前途的纳米平台，用于在红外热（IRT）/MR/CT成像的指导下对肿瘤进行光热/光动力协同治疗。