1-Hydroxymethyl goshuyuamide II (1), a new derivative of evodiamine with a quinazolinocarboline skeleton, along with nine known evodiamine derivatives were isolated from the dried and nearly ripe fruits of Tetradium ruticarpum (A. Jussieu) T. G. Hartley using several different chromatographic separations. Their structures were elucidated on the basis of extensive spectroscopic techniques, including 1D and 2D NMR spectra. Putative biosynthetic pathways toward 1 are proposed. Compounds 1 and 2 and 4 to 10 exhibited cytotoxic activity against six human tumor lines, and compounds 4 and 7 to 10 exhibited moderate inhibitory activity against nitric oxide production in LPS-activated RAW264.7 cells.

使用几种不同的色谱分离方法从Tetradium ruticarpum (A. Jussieu) TG Hartley的干燥和接近成熟的果实中分离出1-Hydroxymethyl goshuyuamide II ( 1 )，一种具有喹唑啉并咔啉骨架的吴茱萸胺的新衍生物，以及九种已知的吴茱萸胺衍生物。它们的结构是在广泛的光谱技术的基础上阐明的，包括 1D 和 2D NMR 光谱。提出了朝向1 的假定生物合成途径。化合物1和2以及4至10对 6 种人类肿瘤系表现出细胞毒活性，化合物4和7至10 在 LPS 激活的 RAW264.7 细胞中表现出对一氧化氮产生的中等抑制活性。