Synthesis and sequencing of informational poly(amino phosphodiester)s,Polymer Chemistry

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Synthesis and sequencing of informational poly(amino phosphodiester)s
Polymer Chemistry ( IF 4.1 ) Pub Date : 2021-09-13 , DOI: 10.1039/d1py01052b
Ian Roszak ₁ , Laurence Oswald ₁ , Abdelaziz Al Ouahabi ₁ , Annabelle Bertin _{1,

2,

3} , Eline Laurent ₁ , Olivier Felix ₁ , Isaure Carvin-Sergent ₄ , Laurence Charles ₄ , Jean-François Lutz ₁

Affiliation

Sequence-defined poly(amino phosphodiester)s containing main-chain tertiary amines were synthesized by automated solid-phase phosphoramidite chemistry. These polymers were prepared using four monomers with different substituents. The formed polymers were characterized by HPLC and mass spectrometry. These methods evidenced preparation of molecularly-defined polymers. Furthermore, the presence of tertiary amines in the polymer backbones facilitates sequencing by tandem mass spectrometry.

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