Stereochemical characterisation of the non-canonical α-humulene synthase from Acremonium strictum,Organic & Biomolecular Chemistry

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Stereochemical characterisation of the non-canonical α-humulene synthase from Acremonium strictum
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2021-09-14 , DOI: 10.1039/d1ob01769a
Houchao Xu ₁ , Carsten Schotte ₂ , Russell J Cox ₂ , Jeroen S Dickschat ₁

Affiliation

The non-canonical fungal α-humulene synthase was investigated through isotopic labelling experiments for its stereochemical course regarding inversion or retention at C-1, the face selectivity at C-11, and the stereoselectivity of the final deprotonation. A new and convenient desymmetrisation strategy was developed to enable a full stereochemical analysis of the catalysed steps to the achiral α-humulene product from stereoselectively labelled farnesyl diphosphate.

中文翻译：

来自严格顶孢霉的非经典 α-葎草烯合酶的立体化学表征

通过同位素标记实验研究了非经典真菌 α-葎草烯合酶的立体化学过程，包括 C-1 处的反转或保留、C-11 处的面选择性以及最终去质子化的立体选择性。开发了一种新的、方便的去对称策略，能够对立体选择性标记的法尼基二磷酸酯生成非手性 α-葎草烯产物的催化步骤进行全面的立体化学分析。

更新日期：2021-09-17

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