Abstract: The occurrence and severity of chemotherapy-induced nausea and vomiting (CINV) are influenced by many factors; this includes therapeutic factors, such as the dose, administration mode, and chemotherapeutic agent emetogenicity, as well as patient-related risk factors, such as the gender, age, alcohol consumption history, and anxiety level. However, these factors cannot fully explain the individual CINV differences. In recent years, the correlation between gene polymorphism and CINV has been a hot research topic; the present paper reviews current research on CINV-related gene polymorphisms, and the results indicate that the use of gene polymorphism for the optimization of CINV efficacy is of important clinical significance.

Keywords: chemotherapy-induced nausea and vomiting, gene polymorphisms, prevention and treatment, antiemetic


中文翻译：

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我们对基因多态性与化疗引起的恶心和呕吐之间关系的理解的更新

摘要：化疗引起的恶心呕吐（CINV）的发生和严重程度受多种因素的影响；这包括治疗因素，例如剂量、给药方式和化疗药物致吐率，以及与患者相关的风险因素，例如性别、年龄、饮酒史和焦虑程度。然而，这些因素并不能完全解释个体 CINV 的差异。近年来，基因多态性与CINV的相关性一直是研究的热点；本文综述了当前CINV相关基因多态性的研究，结果表明利用基因多态性优化CINV疗效具有重要的临床意义。

关键词： 化疗引起的恶心呕吐、基因多态性、防治、止吐