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Association Between Nutritional Risk Screening Score and Prognosis of Patients with Sepsis
Infection and Drug Resistance ( IF 2.9 ) Pub Date : 2021-09-17 , DOI: 10.2147/idr.s321385 Qiqing Gao 1 , Yao Cheng 1 , Zhuohong Li 1 , Qingyun Tang 1 , Rong Qiu 1 , Shaohang Cai 1 , Xuwen Xu 1 , Jie Peng 1 , Hongyan Xie 1
Infection and Drug Resistance ( IF 2.9 ) Pub Date : 2021-09-17 , DOI: 10.2147/idr.s321385 Qiqing Gao 1 , Yao Cheng 1 , Zhuohong Li 1 , Qingyun Tang 1 , Rong Qiu 1 , Shaohang Cai 1 , Xuwen Xu 1 , Jie Peng 1 , Hongyan Xie 1
Affiliation
Background: Malnutrition is one of the most critical factors affecting patients’ risk of infection and length of stay, and it may affect the prognosis of patients with sepsis. There have been no studies that have applied nutritional risk screening tools to stratify patients with sepsis according to prognosis.
Methods: We retrospectively analyzed the clinical data of 425 adult sepsis inpatients who were grouped based on nutritional risk screening (NRS) score, including a nutrition score, disease severity score, and age score. Prognostic factors were analyzed using univariate and multivariate regression analyses.
Results: Of the enrolled patients, 174 had an NRS score of ≥ 3; these patients were older and had a longer hospitalization time but lower body mass index (BMI), albumin (ALB) than others. Univariate Cox regression analysis showed that age, ALB, C-reactive protein (CRP), and NRS score were significantly (P< 0.05) associated with in-hospital mortality. Multivariate analysis showed that age (hazard ratio [HR]=1.020, 95% confidence interval [CI]: 1.005– 1.036; P=0.008) and ALB (HR=0.924, 95% CI: 0.885– 0.966; P< 0.001) were independent risk factors for sepsis-related mortality. The Kaplan–Meier analysis revealed that the cumulative in-hospital mortality of sepsis patients with an NRS score of ≥ 3 was significantly higher than that of patients with an NRS score of < 3 (P=0.022).
Conclusion: NRS scores can effectively risk stratify sepsis patients. Patients with high NRS scores should be monitored more closely to halt further disease progression.
中文翻译：
营养风险筛查评分与脓毒症患者预后的关系
背景：营养不良是影响患者感染风险和住院时间的最关键因素之一，可能影响脓毒症患者的预后。没有研究应用营养风险筛查工具根据预后对脓毒症患者进行分层。
方法：我们回顾性分析了根据营养风险筛查（NRS）评分（包括营养评分、疾病严重程度评分和年龄评分）分组的425例成人脓毒症住院患者的临床资料。使用单变量和多变量回归分析分析预后因素。
结果：入组患者中，174 例 NRS 评分≥3；这些患者年龄较大，住院时间较长，但体重指数（BMI）、白蛋白（ALB）低于其他患者。单变量 Cox 回归分析显示，年龄、ALB、C 反应蛋白（CRP）和 NRS 评分与住院死亡率显着相关（P<0.05）。多变量分析显示，年龄（风险比 [HR]=1.020，95% 置信区间 [CI]：1.005–1.036；P=0.008）和 ALB（HR=0.924，95% CI：0.885–0.966；P<0.001）脓毒症相关死亡率的独立危险因素。Kaplan-Meier 分析显示，NRS 评分≥3 的脓毒症患者的累计住院死亡率显着高于 NRS 评分 < 3 的患者（P=0.022）。
结论：NRS评分可以有效地对脓毒症患者进行风险分层。应更密切地监测 NRS 评分高的患者，以阻止进一步的疾病进展。
更新日期：2021-09-17
Methods: We retrospectively analyzed the clinical data of 425 adult sepsis inpatients who were grouped based on nutritional risk screening (NRS) score, including a nutrition score, disease severity score, and age score. Prognostic factors were analyzed using univariate and multivariate regression analyses.
Results: Of the enrolled patients, 174 had an NRS score of ≥ 3; these patients were older and had a longer hospitalization time but lower body mass index (BMI), albumin (ALB) than others. Univariate Cox regression analysis showed that age, ALB, C-reactive protein (CRP), and NRS score were significantly (P< 0.05) associated with in-hospital mortality. Multivariate analysis showed that age (hazard ratio [HR]=1.020, 95% confidence interval [CI]: 1.005– 1.036; P=0.008) and ALB (HR=0.924, 95% CI: 0.885– 0.966; P< 0.001) were independent risk factors for sepsis-related mortality. The Kaplan–Meier analysis revealed that the cumulative in-hospital mortality of sepsis patients with an NRS score of ≥ 3 was significantly higher than that of patients with an NRS score of < 3 (P=0.022).
Conclusion: NRS scores can effectively risk stratify sepsis patients. Patients with high NRS scores should be monitored more closely to halt further disease progression.
中文翻译：
营养风险筛查评分与脓毒症患者预后的关系
背景：营养不良是影响患者感染风险和住院时间的最关键因素之一，可能影响脓毒症患者的预后。没有研究应用营养风险筛查工具根据预后对脓毒症患者进行分层。
方法：我们回顾性分析了根据营养风险筛查（NRS）评分（包括营养评分、疾病严重程度评分和年龄评分）分组的425例成人脓毒症住院患者的临床资料。使用单变量和多变量回归分析分析预后因素。
结果：入组患者中，174 例 NRS 评分≥3；这些患者年龄较大，住院时间较长，但体重指数（BMI）、白蛋白（ALB）低于其他患者。单变量 Cox 回归分析显示，年龄、ALB、C 反应蛋白（CRP）和 NRS 评分与住院死亡率显着相关（P<0.05）。多变量分析显示，年龄（风险比 [HR]=1.020，95% 置信区间 [CI]：1.005–1.036；P=0.008）和 ALB（HR=0.924，95% CI：0.885–0.966；P<0.001）脓毒症相关死亡率的独立危险因素。Kaplan-Meier 分析显示，NRS 评分≥3 的脓毒症患者的累计住院死亡率显着高于 NRS 评分 < 3 的患者（P=0.022）。
结论：NRS评分可以有效地对脓毒症患者进行风险分层。应更密切地监测 NRS 评分高的患者，以阻止进一步的疾病进展。
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