The increasing prevalence of diabetes and stroke is a major global public health concern. Specifically, acute stroke patients, with pre-existing diabetes, pose a clinical challenge. It is established that diabetes is associated with a worse prognosis after acute stroke and the various biological factors that mediate poor recovery profiles in diabetic patients is unknown. The level of association and impact of diabetes, in the setting of reperfusion therapy, is yet to be determined. This article presents a comprehensive overview of the current knowledge of the role of diabetes in stroke, therapeutic strategies for primary and secondary prevention of cardiovascular disease and/or stroke in diabetes, and various therapeutic considerations that may apply during pre-stroke, acute, sub-acute and post-stroke stages. The early diagnosis of diabetes as a comorbidity for stroke, as well as tailored post-stroke management of diabetes, is pivotal to our efforts to limit the burden. Increasing awareness and involvement of neurologists in the management of diabetes and other cardiovascular risk factors is desirable towards improving stroke prevention and efficacy of reperfusion therapy in acute stroke patients with diabetes.

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糖尿病在中风中的作用：病理生理学和临床管理的最新进展

糖尿病和中风的日益流行是一个主要的全球公共卫生问题。具体而言，患有预先存在糖尿病的急性中风患者构成了临床挑战。已经确定糖尿病与急性卒中后预后较差有关，而介导糖尿病患者恢复不良的各种生物学因素尚不清楚。在再灌注治疗的情况下，糖尿病的关联程度和影响还有待确定。本文全面概述了当前关于糖尿病在中风中的作用的知识、心血管疾病和/或糖尿病中风的一级和二级预防的治疗策略，以及可能适用于中风前、急性、亚-急性和中风后阶段。将糖尿病作为卒中合并症的早期诊断以及针对卒中后糖尿病的定制管理对于我们减轻负担的努力至关重要。提高神经科医生对糖尿病和其他心血管危险因素管理的认识和参与对于改善急性卒中合并糖尿病患者的卒中预防和再灌注治疗的疗效是可取的。