A series of 20 new derivatives of rupestonic acid were synthesized via Davis oxidation. Their antiviral activity against influenza A virus (H3N2) was established. Several of the synthesized compounds were shown to exhibit antiviral activity against influenza A virus. Compound 4d was shown to have the highest potential activity (R = α-methylcinnamyl acyl with IC₅₀ 14.37 μg/mL and TC₅₀ 80.13 μg/mL) against influenza A virus.

中文翻译：

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鲁石酸新衍生物的合成及抗病毒活性

通过戴维斯氧化合成了一系列 20 种新的红石酸衍生物。确定了它们对甲型流感病毒 (H3N2) 的抗病毒活性。几种合成的化合物显示出对甲型流感病毒的抗病毒活性。化合物4d被证明对甲型流感病毒具有最高的潜在活性（R = α-甲基肉桂酰基，IC ₅₀ 14.37 μg/mL 和 TC ₅₀ 80.13 μg/mL）。