An electrochemical sensor was designed and prepared based on a modified-glassy carbon electrode using f-MWCNTs and dopamine. The dopamine is electropolymerized to form a layer of polydopamine on the surface of functionalized carbon nanotubes. Various techniques, including FE-SEM, EDS, elemental mapping, FT-IR, AFM, XRD, and Raman spectroscopy, were used to investigate different prepared catalyst features. Using cyclic voltammetry and EIS techniques, the proposed sensor's potency for ciprofloxacin detection was examined and proved. In the next step, in the DPV technique, different parameters affecting the selectivity and the sensitivity of detection, including pH, pre-concentration potential and time, MWCNTs suspension drop size, and cycle number in the electropolymerization stage, were optimized. Two linear dynamic ranges from 0.075 to 10 μM and from 10 to 100 μM were obtained for ciprofloxacin detection in the optimum condition and using the DPV technique. The detection limit was calculated to be 0.04 μM, and repeatability and reproducibility were found to be 3.2 and 3.3%, respectively. Afterward, the sensor's selectivity against common interfering agents was checked out, and the sensor proved to be highly selective for ciprofloxacin detection. Ciprofloxacin was determined in human plasma and urine samples with desired results at the final stage. The sensor proved to be a trustable tool for ciprofloxacin measurement in clinical and industrial applications.

中文翻译：

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基于改性玻碳电极的选择性电化学传感器，使用 f-MWCNT-聚多巴胺检测环丙沙星


使用 f-MWCNT 和多巴胺，基于改性玻碳电极设计并制备了电化学传感器。多巴胺发生电聚合，在功能化碳纳米管表面形成一层聚多巴胺。使用各种技术，包括FE-SEM、EDS、元素图、FT-IR、AFM、XRD 和拉曼光谱，来研究不同制备的催化剂的特性。使用循环伏安法和 EIS 技术，检查并证明了所提出的传感器检测环丙沙星的功效。下一步，在DPV技术中，对影响检测选择性和灵敏度的不同参数进行了优化，包括pH值、预浓缩电位和时间、MWCNT悬浮液滴尺寸以及电聚合阶段的循环次数。在最佳条件下并使用 DPV 技术检测环丙沙星时获得了 0.075 至 10 μM 和 10 至 100 μM 两个线性动态范围。计算出检测限为 0.04 μM，重复性和再现性分别为 3.2% 和 3.3%。随后，检验了该传感器对常见干扰剂的选择性，证明该传感器对环丙沙星检测具有高度选择性。对人血浆和尿液样本中的环丙沙星进行了测定，并在最后阶段获得了预期的结果。该传感器被证明是临床和工业应用中环丙沙星测量的可靠工具。