Somatoparaphrenia refers to the delusional belief, typically observed in right brain-damaged patients, that the contralesional limbs belong to someone else. Here, we aimed to uncover the neural activity associated with this productive, i.e. confabulatory, component in a patient, S.P.P., with a large right-sided lesion of both cortical and subcortical gray and white matter. He claimed that his left paralyzed hand belonged to his mother. In a block-design functional magnetic resonance (fMRI) experiment, S.P.P. imagined that the mother would move her (i.e. his left) hand (condition “mother”). Subtraction of the activity elicited by control conditions (imagery of self-generated movement of either left or right hand) from that in the “mother” condition resulted in the focal activation of the pars opercularis of the right inferior frontal gyrus (rIFG). In a separate, resting-state fMRI experiment with S.P.P. and 21 healthy controls, we examined the functional connectivity of the rIFG and the affected hand somatosensory network to the rest of the brain. We found a negative correlation between the activity in the rIFG and that of Broca area and the temporo-parietal junction in the left hemisphere. Furthermore, the affected hand somatosensory network was disconnected from the left secondary somatosensory cortex. Our results link the productive component of somatoparaphrenia to the activity of crucial hubs for integrating the multimodal signals of the affected hand. Furthermore, they provide the first direct evidence supporting the “left narrator model”, proposed by Halligan et al. (1995), according to which the confabulations of somatoparaphrenia are due to a disconnection of left hemisphere language areas from right hemisphere parieto-temporal cortex.

Somatoparaphrenia 是指妄想性信念，通常在右脑受损患者中观察到，认为对侧肢体属于其他人。在这里，我们旨在揭示与患者 SPP 的这种生产性（即虚构性）成分相关的神经活动，该患者具有皮质和皮质下灰质和白质的大右侧病变。他声称他左手瘫痪的手属于他的母亲。在块设计功能磁共振 (fMRI) 实验中，SPP 设想母亲会移动她（即他的左手）的手（条件“母亲”）。从“母亲”条件中减去由控制条件（左手或右手自身产生的运动的图像）引起的活动导致右额下回（rIFG）的岛盖部的焦点激活。在对 SPP 和 21 名健康对照组进行单独的静息状态 fMRI 实验中，我们检查了 rIFG 和受影响的手部体感网络与大脑其他部分的功能连接。我们发现 rIFG 的活动与 Broca 区的活动和左半球的颞顶叶交界处的活动呈负相关。此外，受影响的手部体感网络与左侧次级体感皮层断开。我们的结果将躯体功能障碍的生产成分与整合受影响手的多模态信号的关键枢纽的活动联系起来。此外，它们提供了支持 Halligan 等人提出的“左叙述者模型”的第一个直接证据。(1995),