Cocaine triggers gene splicing in brain reward circuits, but the mechanisms and importance of this response are unclear. In this issue of Neuron, Xu et al. (2021) show that the histone modification H3K36me3 marks genes spliced in response to cocaine and, using epigenome editing, establish a causal relationship between gene splicing and addiction-related behavioral responses.

中文翻译：

---

基因剪接为可卡因成瘾奠定了基础

可卡因触发大脑奖励回路中的基因剪接，但这种反应的机制和重要性尚不清楚。在本期Neuron 中，Xu 等人。(2021) 表明组蛋白修饰 H3K36me3 标记响应可卡因剪接的基因，并使用表观基因组编辑建立基因剪接与成瘾相关行为反应之间的因果关系。