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Mass Spectrometric Biosensing: A Powerful Approach for Multiplexed Analysis of Clinical Biomolecules
ACS Sensors ( IF 8.2 ) Pub Date : 2021-09-16 , DOI: 10.1021/acssensors.1c01394 Junjie Hu 1, 2 , Fei Liu 2 , Yunlong Chen 2 , Guoqiang Shangguan 1 , Huangxian Ju 2
ACS Sensors ( IF 8.2 ) Pub Date : 2021-09-16 , DOI: 10.1021/acssensors.1c01394 Junjie Hu 1, 2 , Fei Liu 2 , Yunlong Chen 2 , Guoqiang Shangguan 1 , Huangxian Ju 2
Affiliation
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Rapid and sensitive detection of clinical biomolecules in a multiplexed fashion is of great importance for accurate diagnosis of diseases. Mass spectrometric (MS) approaches are exceptionally suitable for clinical analysis due to its high throughput, high sensitivity, and reliable qualitative and quantitative capabilities. To break through the bottleneck of MS technique for detecting high-molecular-weight substances with low ionization efficiency, the concept of mass spectrometric biosensing has been put forward by adopting mass spectrometric chips to recognize the targets and mass spectrometry to detect the signals switched by the recognition. In this review, the principle of mass spectrometric sensing, the construction of different mass tags used for biosensing, and the typical combination mode of mass spectrometric imaging (MSI) technique are summarized. Future perspectives including the design of portable matching platforms, exploitation of novel mass tags, development of effective signal amplification strategies, and standardization of MSI methodologies are proposed to promote the advancements and practical applications of mass spectrometric biosensing.
中文翻译：
质谱生物传感：一种强大的临床生物分子多重分析方法
以多重方式快速、灵敏地检测临床生物分子对于准确诊断疾病具有重要意义。质谱 (MS) 方法因其高通量、高灵敏度以及可靠的定性和定量能力而特别适用于临床分析。为了突破质谱技术检测高分子量物质电离效率低的瓶颈，提出了质谱生物传感的概念，采用质谱芯片识别靶标，质谱检测由质谱转换的信号。认出。在这篇综述中，质谱传感的原理，用于生物传感的不同质量标签的构建，总结了质谱成像（MSI）技术的典型组合方式。未来的前景包括便携式匹配平台的设计、新型质量标签的开发、有效信号放大策略的开发以及 MSI 方法的标准化，以促进质谱生物传感的进步和实际应用。
更新日期：2021-10-22
中文翻译：
质谱生物传感：一种强大的临床生物分子多重分析方法
以多重方式快速、灵敏地检测临床生物分子对于准确诊断疾病具有重要意义。质谱 (MS) 方法因其高通量、高灵敏度以及可靠的定性和定量能力而特别适用于临床分析。为了突破质谱技术检测高分子量物质电离效率低的瓶颈，提出了质谱生物传感的概念，采用质谱芯片识别靶标，质谱检测由质谱转换的信号。认出。在这篇综述中，质谱传感的原理，用于生物传感的不同质量标签的构建，总结了质谱成像（MSI）技术的典型组合方式。未来的前景包括便携式匹配平台的设计、新型质量标签的开发、有效信号放大策略的开发以及 MSI 方法的标准化，以促进质谱生物传感的进步和实际应用。
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