Shark Tooth-Inspired Microneedle Dressing for Intelligent Wound Management,ACS Nano

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Shark Tooth-Inspired Microneedle Dressing for Intelligent Wound Management
ACS Nano ( IF 15.8 ) Pub Date : 2021-09-17 , DOI: 10.1021/acsnano.1c06279
Maoze Guo ₁ , Yuqiu Wang ₂ , Bingbing Gao ₁ , Bingfang He _{1,

2}

Affiliation

Intelligent management beyond therapeutic drug treating holds significant prospects in facilitating the recovery of intractable chronic wounds. Here, inspired by the flat and inclined structure of shark teeth, we present a shark tooth-inspired microneedle patch for intelligent wound management. By simply replicating negative molds fabricated by laser engraving and using origami, such a biomimetic microneedle patch can be fabricated easily and rapidly. The biomimetic structures endow the microneedle patch with stable adhesion during the long-term recovery process of chronic wounds. Porous ordered structures and a temperature-responsive hydrogel are utilized to construct a controllable drug release system on the microneedle patch. The microfluidic channel composed of microneedle arrays and porous ordered structures enables a microneedle patch with the capacity to analyze several inflammatory factors. In addition, MXene electronics was patterned on the microneedle patch in order to achieve sensitive motion monitoring. Also, it was demonstrated from invivo diabetic rat experiments that recovery of full-thickness cutaneous wounds including stripe-shaped and circular wounds can be facilitated by employing the drug-loaded biomimetic microneedle patch.

中文翻译：

用于智能伤口管理的鲨鱼牙微针敷料

治疗药物治疗之外的智能管理在促进顽固性慢性伤口的恢复方面具有重要的前景。在这里，受到鲨鱼牙齿扁平和倾斜结构的启发，我们展示了一种受鲨鱼牙齿启发的微针贴片，用于智能伤口管理。通过简单地复制激光雕刻和使用折纸制作的阴模，这种仿生微针贴片可以轻松快速地制造。仿生结构使微针贴片在慢性伤口的长期恢复过程中具有稳定的粘附力。利用多孔有序结构和温度响应水凝胶在微针贴片上构建可控的药物释放系统。由微针阵列和多孔有序结构组成的微流体通道使微针贴片能够分析多种炎症因子。此外，MXene 电子元件被图案化在微针贴片上，以实现灵敏的运动监测。此外，它是从显示出在体内糖尿病大鼠实验表明，通过使用载药仿生微针贴片，可以促进全层皮肤伤口的恢复，包括条形和圆形伤口。

更新日期：2021-09-28

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