De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation,Circulation Research

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De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation
Circulation Research ( IF 16.5 ) Pub Date : 2021-09-17 , DOI: 10.1161/circresaha.121.319004
Hao Li _{1,

2} , Yoonhee Nam ₃ , Ran Huo _{1,

2} , Weilun Fu _{1,

2} , Biaobin Jiang _{4,

5} , Qiuxia Zhou ₃ , Dong Song ₃ , Yingxi Yang _{4,

5} , Yuming Jiao _{1,

2} , Jiancong Weng _{1,

2} , Zihan Yan _{1,

2} , Lin Di _{6,

7} , Jie Li ₈ , Jie Wang _{1,

2} , Hongyuan Xu _{1,

2} , Shuo Wang _{1,

2} , Jizong Zhao _{1,

2} , Zilong Wen _{3,

9} , Jiguang Wang _{3,

4,

10} , Yong Cao _{1,

2,

11}

Affiliation

Neurosurgery, Beijing Tiantan Hospital (H.L., R.H., W.F., Y.J., Jiancong Weng, Z.Y., Jie Wang, H.X., S.W., J.Z., Y.C.), Capital Medical University, China.
China National Clinical Research Center for Neurological Diseases, Beijing, China (H.L., R.H., W.F., Y.J., Jiancong Weng, Z.Y., Jie Wang, H.X., S.W., J.Z., Y.C.).
Division of Life Science, State Key Laboratory of Molecular Neuroscience (Y.N., Q.Z., D.S., Z.W., Jiguang Wang), Clear Water Bay, Kowloon, Hong Kong SAR, China.
Chemical and Biological Engineering (B.J., Y.Y., Jiguang Wang), Clear Water Bay, Kowloon, Hong Kong SAR, China.
the Hong Kong University of Science and Technology (B.J.,Y.Y.), Clear Water Bay, Kowloon, Hong Kong SAR, China.
Beijing Advanced Innovation Center for Genomics, Biomedical Pioneering Innovation Center, Peking-Tsinghua Center for Life Sciences (L.D.), Peking University, Beijing, China.
School of Life Sciences (L.D.), Peking University, Beijing, China.
School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China (J.L.).
Greater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, China (Z.W.).
Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong SAR, China (Jiguang Wang).
Beijing Neurosurgical Institute (Y.C.), Capital Medical University, China.