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Transcranial magnetic stimulation entrains alpha oscillatory activity in occipital cortex
Scientific Reports ( IF 3.8 ) Pub Date : 2021-09-17 , DOI: 10.1038/s41598-021-96849-9
Yong-Jun Lin 1 , Lavanya Shukla 2 , Laura Dugué 1, 2, 3, 4 , Antoni Valero-Cabré 5, 6, 7 , Marisa Carrasco 1, 2
Affiliation  

Parieto-occipital alpha rhythms (8–12 Hz) underlie cortical excitability and influence visual performance. Whether the synchrony of intrinsic alpha rhythms in the occipital cortex can be entrained by transcranial magnetic stimulation (TMS) is an open question. We applied 4-pulse, 10-Hz rhythmic TMS to entrain intrinsic alpha oscillators targeting right V1/V2, and tested four predictions with concurrent electroencephalogram (EEG): (1) progressive enhancement of entrainment across time windows, (2) output frequency specificity, (3) dependence on the intrinsic oscillation phase, and (4) input frequency specificity to individual alpha frequency (IAF) in the neural signatures. Two control conditions with an equal number of pulses and duration were arrhythmic-active and rhythmic-sham stimulation. The results confirmed the first three predictions. Rhythmic TMS bursts significantly entrained local neural activity. Near the stimulation site, evoked oscillation amplitude and inter-trial phase coherence (ITPC) were increased for 2 and 3 cycles, respectively, after the last TMS pulse. Critically, ITPC following entrainment positively correlated with IAF rather than with the degree of similarity between IAF and the input frequency (10 Hz). Thus, we entrained alpha-band activity in occipital cortex for ~ 3 cycles (~ 300 ms), and IAF predicts the strength of entrained occipital alpha phase synchrony indexed by ITPC.



中文翻译:

经颅磁刺激引起枕叶皮层的α振荡活动

顶枕叶阿尔法节律 (8–12 Hz) 是皮质兴奋性的基础并影响视觉表现。经颅磁刺激 (TMS) 是否可以引起枕叶皮层内在 alpha 节律的同步性是一个悬而未决的问题。我们应用 4 脉冲、10 赫兹节律 TMS 来引入针对右 V1/V2 的固有 alpha 振荡器,并使用并发脑电图 (EEG) 测试了四个预测:(1) 跨时间窗的夹带逐渐增强,(2) 输出频率特异性,(3) 对固有振荡相位的依赖性,以及 (4) 输入频率对神经特征中单个 alpha 频率 (IAF) 的特异性。具有相同脉冲数和持续时间的两个控制条件是心律失常活跃刺激和节律假刺激。结果证实了前三个预测。有节奏的 TMS 爆发显着夹带局部神经活动。在刺激部位附近,在最后一个 TMS 脉冲后,诱发振荡幅度和试验间相干性 (ITPC) 分别增加了 2 个和 3 个周期。至关重要的是,夹带后的 ITPC 与 IAF 正相关,而不是 IAF 与输入频率(10 Hz)之间的相似程度。因此,我们在枕叶皮层中引入 alpha 波段活动 ~ 3 个周期(~ 300 ms),IAF 预测由 ITPC 索引的被引入的枕叶 alpha 相位同步的强度。夹带后的 ITPC 与 IAF 呈正相关,而不是与 IAF 和输入频率 (10 Hz) 之间的相似程度相关。因此,我们在枕叶皮层中引入 alpha 波段活动 ~ 3 个周期(~ 300 ms),IAF 预测由 ITPC 索引的被引入的枕叶 alpha 相位同步的强度。夹带后的 ITPC 与 IAF 呈正相关,而不是与 IAF 和输入频率 (10 Hz) 之间的相似程度相关。因此,我们在枕叶皮层中引入 alpha 波段活动 ~ 3 个周期(~ 300 ms),IAF 预测由 ITPC 索引的被引入的枕叶 alpha 相位同步的强度。

更新日期:2021-09-17
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