Coronary artery stenosis is the most common heart disease, leading to altered myocardial mechanics. This study aimed to compare Ghista–Sandler and Mirsky wall stress models and evaluate the discriminant analysis of noninvasive wall stress based on these models. 59 Coronary artery disease (CAD) patients were divided into two groups; moderate stenosis and severe stenosis in the left anterior descending artery proximal part were enrolled in this study. The wall stress in the end-systolic and end-diastolic phases at LV anterior and interventricular septum wall segments calculated by using the equation proposed by Ghista–Sandler and Mirsky. The specificity and sensitivity of wall stress at groups were calculated by Ghista–Sandler and Mirsky models. The wall thickness and principal radius of segments in healthy subjects and patients with severe and moderate stenosis were shown statistically differences in some segments of anterior and septum walls (p<0.05). Statistical analysis showed that calculated stresses in myocardial wall segments of patients with severe and moderate coronary stenosis and healthy people had a significant difference in systole and diastolic phase. Results of the discriminant analysis showed the specificity value obtained by the Ghista–Sandler model were higher in most wall stress combinations than the Mirsky model. Sensitivity in identifying patients with severe stenosis was higher in the Ghista–Sandler model. It is concluded that specificity and sensitivity based on wall stresses calculated by the Ghista–Sandler model were higher in comparison with the Mirsky model. The Ghista–Sandler model has better performance than the Mirsky model in diagnosing patients with stenosis.

中文翻译：

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两种厚壳模型在心肌壁应力无创评估中的性能比较

冠状动脉狭窄是最常见的心脏病，会导致心肌力学改变。本研究旨在比较 Ghista-Sandler 和 Mirsky 壁应力模型，并评估基于这些模型的无创壁应力的判别分析。将59例冠状动脉疾病（CAD）患者分为两组；本研究纳入左前降支近端中度狭窄和重度狭窄。使用 Ghista-Sandler 和 Mirsky 提出的方程计算 LV 前壁和室间隔壁段的收缩末期和舒张末期的壁应力。通过 Ghista-Sandler 和 Mirsky 模型计算各组壁应力的特异性和敏感性。p<0.05）。统计分析表明，重、中度冠状动脉狭窄患者与健康人心肌壁节段的计算应力在收缩期和舒张期有显着差异。判别分析的结果表明，在大多数壁应力组合中，Ghista-Sandler 模型获得的特异性值高于 Mirsky 模型。在 Ghista-Sandler 模型中，识别严重狭窄患者的敏感性更高。得出的结论是，与 Mirsky 模型相比，基于 Ghista-Sandler 模型计算的壁应力的特异性和敏感性更高。Ghista-Sandler 模型在诊断狭窄患者方面的性能优于 Mirsky 模型。