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Comment on “Aberrant type 1 immunity drives susceptibility to mucosal fungal infections”
Science ( IF 44.7 ) Pub Date : 2021-09-17 , DOI: 10.1126/science.abi5459
Anne Puel 1, 2, 3, 4 , Jean-Laurent Casanova 1, 2, 3, 4
Affiliation  

Break et al. (Research Articles, 15 January 2021, eaay5731) suggest that chronic mucocutaneous candidiasis in humans with inborn errors of AIRE and autoimmune polyendocrine syndrome type 1 is due to excessive interferon-γ production and not to autoantibodies neutralizing interleukin-17 cytokines. We argue that both claims are not conclusively supported by their data and are at odds with 35 years of study.

中文翻译:

评论“异常的 1 型免疫导致对粘膜真菌感染的易感性”

打破等人。(研究文章,2021 年 1 月 15 日,eaay5731)表明患有先天性AIRE错误和 1 型自身免疫性多内分泌综合征的人类慢性皮肤黏膜念珠菌病是由于干扰素-γ 产生过多,而不是由于自身抗体中和了白介素 17 细胞因子。我们认为,这两种说法都没有得到他们的数据的最终支持,并且与 35 年的研究不一致。
更新日期:2021-09-17
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