Therapeutic discovery for mantle cell lymphoma (MCL) has been hindered by a lack of preclinical mouse models that recapitulate human disease. In this issue, Pieters and colleagues (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202280) establish a novel mouse model of MCL driven by overexpression of cyclin D2 and identify fetal-derived B1a cells as putative cell of origin for MCL.

中文翻译：

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通晓 B1a：揭开套细胞淋巴瘤的起源

由于缺乏重现人类疾病的临床前小鼠模型，套细胞淋巴瘤（MCL）的治疗发现受到阻碍。在本期中，Pieters 及其同事 (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202280) 建立了一种由细胞周期蛋白 D2 过度表达驱动的新型 MCL 小鼠模型，并鉴定了胎儿来源的 B1a 细胞作为 MCL 的假定起源细胞。