Genetic characterization of Carbapenem-Resistant Escherichia coli from China, 2015–2017,BMC Microbiology

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Genetic characterization of Carbapenem-Resistant Escherichia coli from China, 2015–2017
BMC Microbiology ( IF 4.0 ) Pub Date : 2021-09-17 , DOI: 10.1186/s12866-021-02307-x
Fengtian Li ₁ , Kun Ye ₁ , Xin Li ₁ , Liyan Ye ₁ , Ling Guo ₁ , Lifeng Wang ₁ , Jiyong Yang ₁

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The molecular characteristics of carbapenem-resistant Escherichia coli (CREco) remain unclear. We conducted a multi-center bacterial resistance monitoring project from 2015 to 2017.The minimum inhibitory concentrations ofCREco were determined bybroth microdilution method. The genome sequencing of CREcoisolates was performed, and single-nucleotide polymorphism (SNP) was analyzed. A total of 144CREcoisolatescollected from 10 cities in China were involved in this study. ST167 (n = 43) is the most popular type, followed by ST410(n = 14), ST131(n = 9). There were 102 (70.83%) CREco isolates that produced various NDMs, including NDM-1 (n = 16), NDM-4(n = 1), NDM-5(n = 79), NDM-6(n = 2) and NDM-9(n = 4). In addition, 15 isolates produced KPC-2, three isolates wereIMP-4 positive, and three isolates produced OXA-48. Genetic relatedness and phylogenetic analysis showed that isolates with the same ST had a high degree of homology. Some STs (including ST167, ST410, ST131, ST46, ST405 and ST617) exhibited a trend of outbreak. The majority of CREco belonged to ST167, followed by ST410 and ST131, and most of them carried various NDM-coding genes. The spread of high-risk clones of CREco has occurred in different regions of China.

更新日期：2021-09-17

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