The relationship between serum lipids and cholecystitis is still under investigation. To examine the causal effect of serum lipids on cholecystitis using the Mendelian randomization method. We conducted univariable Mendelian randomization (MR) analyses using summary statistics from two independent genome-wide association studies (GWAS) on serum lipids (n = 132,908) and cholecystitis (n = 361,194). Mainly, the inverse-variance weighted (IVW) method was utilized to combine each SNP’s causal estimation, and the MR-Egger was adopted as a complementary method, together with the weighted median. Cochrane’s Q value was employed to appraise heterogeneity. The MR-Egger intercept and MR-PRESSO were used to detect the horizontal pleiotropy. Our univariable results displayed a minor protective effect of serum low-density lipoprotein (LDL) cholesterol (OR [95% CI] = 0.9984483 [0.9984499, 0.9984468]; p = 0.008) on cholecystitis. No significant causal effect of total cholesterol (TC) (OR [95% CI] = 0.9994228 [0.9994222, 0.9994233]; p = 0.296), triglycerides (OR [95% CI] = 0.9990893 [0.9990882, 0.9990903]; p = 0.238) and high-density lipoprotein (HDL) cholesterol (OR [95% CI] = 0.9997020 [0.9997017, 0.9997023]; p = 0.565) was found on cholecystitis. These findings suggest that LDL cholesterolhas a slight protective effect on cholecystitis, which can be easily affected by confounding factors. TC, triglycerides and HDL cholesterol don’t have causal effect on cholecystitis. The protective effect of serum lipids on cholecystitis, though possible, remain less certain.

中文翻译：

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孟德尔随机化排除了血脂与胆囊炎之间的因果关系


血脂与胆囊炎之间的关系仍在研究中。使用孟德尔随机化方法检查血清脂质对胆囊炎的因果影响。我们使用两项关于血清脂质 (n = 132,908) 和胆囊炎 (n = 361,194) 的独立全基因组关联研究 (GWAS) 的汇总统计数据进行了单变量孟德尔随机化 (MR) 分析。主要利用逆方差加权(IVW)方法结合各个SNP的因果估计，并采用MR-Egger作为补充方法，与加权中位数一起。 Cochrane的Q值被用来评价异质性。 MR-Egger截距和MR-PRESSO用于检测水平多效性。我们的单变量结果显示血清低密度脂蛋白 (LDL) 胆固醇 (OR [95% CI] = 0.9984483 [0.9984499, 0.9984468]; p = 0.008) 对胆囊炎有轻微的保护作用。总胆固醇 (TC)（OR [95% CI] = 0.9994228 [0.9994222, 0.9994233]；p = 0.296）、甘油三酯（OR [95% CI] = 0.9990893 [0.9990882, 0.9990903]；p = 0.238）没有显着因果效应胆囊炎中发现高密度脂蛋白 (HDL) 胆固醇 (OR [95% CI] = 0.9997020 [0.9997017, 0.9997023]；p = 0.565)。这些发现表明，低密度脂蛋白胆固醇对胆囊炎有轻微的保护作用，而胆囊炎很容易受到混杂因素的影响。 TC、甘油三酯和HDL胆固醇与胆囊炎没有因果关系。血清脂质对胆囊炎的保护作用虽然可能，但仍不确定。