Background:Studies have found that blood lipids are associated with plasma amyloid-β (Aβ) levels, but the underlying mechanism is still unclear. Two Aβ transporters, soluble form of low-density lipoprotein receptor related protein-1 (sLRP1) and soluble receptor of advanced glycation end products (sRAGE), are crucial in peripheral Aβ transport. Objective:The aim was to investigate the effects of lipids on the relationships between plasma Aβ and transporter levels. Methods:This study included 1,436 adults aged 40 to 88 years old. Blood Aβ, sLRP1, sRAGE, and lipid levels were measured. Univariate and multivariate analyses were used to analyze the relationships between lipids and plasma Aβ, sLRP1, and sRAGE. Results:After adjusting for all possible covariates, high-density lipoprotein (HDL-c) was positively associated with plasma Aβ 42 and sRAGE (β= 6.158, p = 0.049; β= 121.156, p < 0.001, respectively), while triglyceride (TG) was negatively associated with plasma Aβ 40, Aβ 42, and sRAGE (β= –48.389, p = 0.017; β= –11.142, p = 0.020; β= –147.937, p = 0.003, respectively). Additionally, positive correlations were found between plasma Aβ and sRAGE in the normal TG (Aβ 40: β= 0.034, p = 0.005; Aβ 42: β= 0.010, p = 0.001) and HDL-c groups (Aβ 40: β= 0.023, p = 0.033; Aβ 42: β= 0.008, p = 0.002) but not in the high TG and low HDL-c groups. Conclusion:Abnormal levels of TG and HDL-c are associated with decreased Aβ and sRAGE levels. Positive correlations between plasma Aβ and sRAGE were only found in the normal TG and HDL-c groups but not in the high TG and low HDL-c groups. These results indicated that dyslipidemia contributing to plasma Aβ levels might also be involved in peripheral Aβ clearance.

中文翻译：

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血液甘油三酯和高密度脂蛋白水平与血浆淀粉样蛋白 β 转运相关：一项基于人群的横断面研究

背景：研究发现血脂与血浆淀粉样蛋白-β（Aβ）水平有关，但其潜在机制尚不清楚。两种 Aβ 转运蛋白，可溶性形式的低密度脂蛋白受体相关蛋白 1 (sLRP1) 和可溶性晚期糖基化终产物受体 (sRAGE)，在外周 Aβ 转运中至关重要。目的：研究脂质对血浆Aβ与转运蛋白水平关系的影响。方法：本研究包括 1,436 名 40 至 88 岁的成年人。测量血液 Aβ、sLRP1、sRAGE 和脂质水平。使用单变量和多变量分析来分析脂质与血浆 Aβ、sLRP1 和 sRAGE 之间的关系。结果：调整所有可能的协变量后，高密度脂蛋白 (HDL-c) 与血浆 Aβ 42 和 sRAGE (β= 6. 158, p = 0.049; β= 121.156，分别为 p < 0.001），而甘油三酯 (TG) 与血浆 Aβ 40、Aβ 42 和 sRAGE 呈负相关（β= –48.389，p = 0.017；β= –11.142，p = 0.020； –147.937，分别为 p = 0.003）。此外，在正常 TG（Aβ 40：β= 0.034，p = 0.005；Aβ 42：β= 0.010，p = 0.001）和 HDL-c 组（Aβ 40：β= 0.023）中发现血浆 Aβ 和 sRAGE 之间存在正相关, p = 0.033; Aβ 42: β = 0.008, p = 0.002) 但不是在高 TG 和低 HDL-c 组中。结论：TG和HDL-c水平异常与Aβ和sRAGE水平降低有关。血浆 Aβ 和 sRAGE 之间的正相关仅在正常 TG 和 HDL-c 组中发现，而在高 TG 和低 HDL-c 组中没有。