PURPOSE To retrospectively analyze the safety and efficacy of transcatheter arterial chemoembolization (TACE) in super-aged patients with advanced gastric cancer (AGC), as well as the effects of TACE on quality of life (QOL) and anxiety state. METHODS In this study, 32 AGC patients aged over 80 years old were enrolled and treated with TACE. Complications of TACE and total effective rate of symptom relief after TACE were observed. Changes of the maximum diameter of solid tumors before and after TACE were compared by reexamination of abdominal computerized tomography. QOL, Eastern Cooperative Oncology Group (ECOG), and Hamilton anxiety scale (HAMA) scores of tumor patients were performed before TACE and 3d, 28d, and 90d after TACE. RESULTS No serious complications occurred during or after TACE in any patient. The total effective rate of symptom relief was 56.25% at 28d after TACE and 71.88% at 90d after TACE. Compared with before TACE, the maximum diameter of tumor was significantly decreased after TACE; ECOG was increased at 3d after TACE, while was decreased at 28d and 90d after TACE (P < 0.05); QOL and HAMA had no significant change at 3d after TACE, while increased significantly at 28d and 90d after TACE (all P < 0.05). CONCLUSION TACE was safe and effective, could shrink tumors, and improve the QOL and anxiety for super-aged patients with AGC.

中文翻译：

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超高龄晚期胃癌患者经导管动脉化疗栓塞的临床观察

目的回顾性分析经导管动脉化疗栓塞术（TACE）治疗超老年晚期胃癌（AGC）患者的安全性和有效性，以及TACE对生活质量（QOL）和焦虑状态的影响。方法 在这项研究中，32 名年龄在 80 岁以上的 AGC 患者被纳入并接受 TACE 治疗。观察TACE并发症及TACE后症状缓解总有效率。通过腹部CT复查比较TACE前后实体瘤最大直径的变化。分别于TACE前及TACE后3、28、90天对肿瘤患者的生活质量、东部肿瘤协作组（ECOG）、汉密尔顿焦虑量表（HAMA）评分进行评分。结果 任何患者在 TACE 期间或之后均未发生严重并发症。TACE后28d症状缓解总有效率为56.25%，TACE后90d为71.88%。与TACE前相比，TACE后肿瘤最大直径明显减小；ECOG在TACE后3d升高，在TACE后28d和90d降低（P < 0.05）；TACE后3d QOL和HAMA无显着变化，TACE后28d和90d显着升高（均P < 0.05）。结论 TACE安全有效，可缩小肿瘤，改善超高龄AGC患者的生活质量和焦虑。TACE后3d QOL和HAMA无显着变化，TACE后28d和90d显着升高（均P < 0.05）。结论 TACE安全有效，可缩小肿瘤，改善超高龄AGC患者的生活质量和焦虑。TACE后3d QOL和HAMA无显着变化，TACE后28d和90d显着升高（均P < 0.05）。结论 TACE安全有效，可缩小肿瘤，改善超高龄AGC患者的生活质量和焦虑。