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Branched-chain amino acids regulate hyaluronan synthesis and PPARα expression in the skin.
Bioscience, Biotechnology, and Biochemistry ( IF 1.4 ) Pub Date : 2021-10-21 , DOI: 10.1093/bbb/zbab160
Takumi Yamane 1 , Yasuyuki Kitaura 2 , Ken Iwatsuki 1 , Yoshiharu Shimomura 3 , Yuichi Oishi 1
Affiliation  

We examined the effects of deletion of branched-chain α-keto acid dehydrogenase kinase (BDK), a key enzyme in branched-chain amino acid catabolism, on hyaluronan synthesis in mice. The skin levels of hyaluronan and the gene expression levels of hyaluronan synthase (Has)2, Has3, and peroxisome proliferator-activated receptor-α were significantly lower in the BDK-knockout group than in the wild-type group.

中文翻译:


支链氨基酸调节皮肤中透明质酸的合成和 PPARα 的表达。



我们研究了支链 α-酮酸脱氢酶激酶 (BDK)(支链氨基酸分解代谢中的关键酶)的缺失对小鼠透明质酸合成的影响。 BDK敲除组的皮肤透明质酸水平以及透明质酸合酶(Has)2、Has3和过氧化物酶体增殖物激活受体-α的基因表达水平显着低于野生型组。
更新日期:2021-09-16
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