We examined the effects of deletion of branched-chain α-keto acid dehydrogenase kinase (BDK), a key enzyme in branched-chain amino acid catabolism, on hyaluronan synthesis in mice. The skin levels of hyaluronan and the gene expression levels of hyaluronan synthase (Has)2, Has3, and peroxisome proliferator-activated receptor-α were significantly lower in the BDK-knockout group than in the wild-type group.

中文翻译：

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支链氨基酸调节皮肤中透明质酸的合成和 PPARα 的表达。


我们研究了支链 α-酮酸脱氢酶激酶 (BDK)（支链氨基酸分解代谢中的关键酶）的缺失对小鼠透明质酸合成的影响。 BDK敲除组的皮肤透明质酸水平以及透明质酸合酶（Has）2、Has3和过氧化物酶体增殖物激活受体-α的基因表达水平显着低于野生型组。