A new homocysteine thiolactone derivative, thiolactomide (1), was isolated along with a known compound, N-acetyl homocysteine thiolactone (2), from a culture extract of soil-derived Streptomyces sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses with literature study. Biological evaluation studies revealed that both 1 and 2 exhibit neuroprotective activity against 6-hydroxydopamine (6-OHDA) mediated neurotoxicity by blocking generation of hydrogen peroxide in neuroblastoma SH-SY5Y cells.

中文翻译：

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Thiolactomide：一种来自链霉菌属的新同型半胱氨酸硫内酯衍生物。具有神经保护活性。

一种新的同型半胱氨酸硫内酯衍生物 thiolactomide ( 1 ) 与一种已知化合物N-乙酰同型半胱氨酸硫内酯 ( 2 ) 从土壤来源的链霉菌属的培养物提取物中分离出来。RK88-1441。通过详细的 NMR 和 MS 光谱分析以及文献研究阐明了这些化合物的结构。生物学评估研究表明，1和2通过阻断神经母细胞瘤 SH-SY5Y 细胞中过氧化氢的产生，对 6-羟基多巴胺 (6-OHDA) 介导的神经毒性具有神经保护活性。