Background Osteoporosis is a common complication of acute fracture, which can lead to fracture delayed union or other complications and resulting in poor fracture healing. Bisphosphate is a common anti-osteoporosis drug, but its application in fracture patients is still controversial because of its inhibitory effect on bone resorption. Method Studies were acquired from literature databases in accordance with established inclusion criteria. Standard mean difference (SMD) and 95% confidence intervals (Cls) were calculated to evaluate the effectiveness of the bisphosphonates treatment in fracture patients. Data analysis was conducted with the Review Manager 5.4.1 software. Results A total of 16 studies involving 5022 patients obtained from selected databases were examined. As expected, bisphosphate had no significant effect on fracture healing time, but it could significantly increase BMD and prevent osteoporosis. Meanwhile, bisphosphate can inhibit both bone resorption and bone formation markers, resulting in low bone turnover state. Conclusion This meta-analysis showed that bisphosphonate have no significant effect on fracture healing time but they do increase the changes in BMD and reduce bone synthesis and resorption markers. Early application of bisphosphonates after injury in the appropriate patient population should be considered.

中文翻译：

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双膦酸盐对骨折愈合时间和骨密度变化的影响：荟萃分析。

背景骨质疏松症是急性骨折的常见并发症，可导致骨折延迟愈合或其他并发症，导致骨折愈合不良。双磷酸盐是一种常见的抗骨质疏松药物，但由于其对骨吸收的抑制作用，其在骨折患者中的应用仍存在争议。方法研究是根据既定的纳入标准从文献数据库中获得的。计算标准平均差 (SMD) 和 95% 置信区间 (Cls) 以评估双膦酸盐治疗对骨折患者的有效性。使用 Review Manager 5.4.1 软件进行数据分析。结果 共检查了 16 项研究，涉及从选定数据库中获得的 5022 名患者。正如预期的那样，双磷酸盐对骨折愈合时间没有显着影响，但它可以显着增加BMD并预防骨质疏松症。同时，二磷酸盐可以抑制骨吸收和骨形成标志物，导致低骨转换状态。结论 该荟萃分析表明，双膦酸盐对骨折愈合时间没有显着影响，但它们确实会增加 BMD 的变化并降低骨合成和再吸收标志物。应考虑在适当的患者人群中在受伤后早期应用双膦酸盐。结论 该荟萃分析表明，双膦酸盐对骨折愈合时间没有显着影响，但它们确实会增加 BMD 的变化并降低骨合成和再吸收标志物。应考虑在适当的患者人群中在受伤后早期应用双膦酸盐。结论 该荟萃分析表明，双膦酸盐对骨折愈合时间没有显着影响，但它们确实会增加 BMD 的变化并降低骨合成和再吸收标志物。应考虑在适当的患者人群中在受伤后早期应用双膦酸盐。