BACKGROUND Appreciation of unique presentation, patterns and underlying pathophysiology of coronary artery disease in women has driven gender based risk stratification and risk reduction efforts over the last decade. Data regarding whether these advances have resulted in unequivocal improvements in outcomes of CABG in women is conflicting. The objective of our study was to assess gender differences in post-operative outcomes following CABG. METHODS Retrospective analyses of institutional data housed in the Society of Thoracic Surgeons (STS) database for patients undergoing CABG between 2002 and 2020 were conducted. Multivariable regression analysis was conducted to investigate gender differences in post-operative outcomes. P-values were adjusted using Bonferroni correction to reduce type-I errors. RESULTS Our final cohort of 6,250 patients had fewer women than men (1,339 vs. 4,911). more women were diabetic (52.0% vs. 41.2%, p<0.001) and hypertensive (89.1% vs. 84.0%, p<0.001). Women had higher adjusted odds of developing ventilator dependence >48 hours (OR: 1.65 [1.21, 2.45], p = 0.002) and cardiac readmissions (OR: 1.56 [1.27, 2.30], p = 0.003). After adjustment for comorbidity burden, mortality rates in women were comparable to those of age-matched men. CONCLUSION The findings of our study indicate that despite apparent reduction of differences in mortality, the burden of postoperative morbidity is still high among women.

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更新：CABG 结果中的性别差异 - 我们是否弥合了差距？

背景 在过去十年中，对女性冠状动脉疾病的独特表现、模式和潜在病理生理学的认识推动了基于性别的风险分层和降低风险的努力。关于这些进步是否导致女性 CABG 结果的明确改善的数据是相互矛盾的。我们研究的目的是评估 CABG 术后结果的性别差异。方法 对胸外科医师协会 (STS) 数据库中 2002 年至 2020 年期间接受 CABG 的患者的机构数据进行了回顾性分析。进行多变量回归分析以调查术后结果的性别差异。使用 Bonferroni 校正调整 P 值以减少 I 型错误。结果 我们的最后一组 6 人，250 名患者的女性人数少于男性（1,339 对 4,911）。更多的女性患有糖尿病（52.0% 对 41.2%，p<0.001）和高血压（89.1% 对 84.0%，p<0.001）。女性发生呼吸机依赖 > 48 小时（OR：1.65 [1.21, 2.45]，p = 0.002）和心脏再入院（OR：1.56 [1.27, 2.30]，p = 0.003）的调整几率更高。调整合并症负担后，女性的死亡率与年龄匹配的男性相当。结论我们的研究结果表明，尽管死亡率差异明显减少，但女性术后发病率的负担仍然很高。45]，p = 0.002）和心脏再入院（OR：1.56 [1.27, 2.30]，p = 0.003）。调整合并症负担后，女性的死亡率与年龄匹配的男性相当。结论我们的研究结果表明，尽管死亡率差异明显减少，但女性术后发病率的负担仍然很高。45]，p = 0.002）和心脏再入院（OR：1.56 [1.27, 2.30]，p = 0.003）。调整合并症负担后，女性的死亡率与年龄匹配的男性相当。结论我们的研究结果表明，尽管死亡率差异明显减少，但女性术后发病率的负担仍然很高。