The Hippo pathway is an evolutionarily and functionally conserved signalling pathway that controls organ size by regulating cell proliferation, apoptosis, and differentiation. Emerging evidence has shown that the Hippo pathway plays critical roles in cardiac development, homeostasis, disease, and regeneration. Targeting the Hippo pathway has tremendous potential as a therapeutic strategy for treating intractable cardiovascular diseases, such as heart failure. In this review, we summarize the function of the Hippo pathway in the heart. Particularly, we highlight the post-translational modification of Hippo pathway components, including the core kinases LATS1/2 and their downstream effectors YAP/TAZ, in different contexts, which has provided new insights and avenues in cardiac research.

中文翻译：

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针对心脏修复中的 Hippo 通路

Hippo 通路是一种进化上和功能上保守的信号通路，通过调节细胞增殖、凋亡和分化来控制器官大小。新出现的证据表明，Hippo 通路在心脏发育、体内平衡、疾病和再生中起关键作用。靶向 Hippo 通路作为治疗难治性心血管疾病（如心力衰竭）的治疗策略具有巨大潜力。在这篇综述中，我们总结了 Hippo 通路在心脏中的功能。特别是，我们强调了 Hippo 通路成分的翻译后修饰，包括核心激酶 LATS1/2 及其下游效应子 YAP/TAZ，在不同的背景下，这为心脏研究提供了新的见解和途径。